Porphyrins, Fractionated, Quantitative, Urine

Last Modified: 10/24/2019 2:22:24 PM


Specimen Requirements:

2.0 mL random Urine collection in a Yellow Capped Container, placed in amber bag.
Collection Instructions: Protect from light by placing the urine cup in an Amber bag or by wrapping in foil

Random urine collected with 5 grams of sodium carbonate, refrigerated and protected from light during collection is preferred. 
Collection with no preservative is acceptable, if properly refrigerated and light protected.

Minimum Volume: 3.0 mL
Transport & Storage: Temperature/Stability:

7 days Refrigerated
30 days Frozen (preferred)
Rejection Criteria: Received Ambient; Not protected from light; pH less than 4.0
Reference Range:
Uroporphyrin I:                            3.6 - 21.1            mcg/g creat
Uroporphyrin III:                          < or = 5.6            mcg/g creat
Heptacarboxyporphyrin:            < or = 3.4            mcg/g creat
Hexacarboxyporphyrin:              < or = 6.3            mcg/g creat
Pentacarboxyporphyrin:             < or = 4.1            mcg/g creat
Coproporphyrin I:                        6.5 - 33.2            mcg/g creat
Coproporphyrin III:                      4.8 - 88.6            mcg/g creat
Total Porphyrins:                         27.0 - 153.6       mcg/g creat
Methodology: High Performance Liquid Chromatography
Clinical Significance: Urinary Porphobilinogen is the first step in the diagnosis of acute intermittent prophyria (AIP). Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 5 days
Days Performed: Sunday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 36592
Alternate Test Names: Porphyrins, Random Urine
CPT Coding: 84120

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