Protein S Antigen, Total

Overview

  • EPIC Code:
  • LAB2639
  • Soft Test Code:
  • Send Out Test Code:
  • 5165
Alternate Names
  • Protein S Ag, Total
  • Protein S, Total Ag
  • Protein S, Total Antigen
  • PSAG
Clinical Significance

The congenital or acquired deficiency of protein S increases the risk for thromboembolism, owing to a decrease of blood anticoagulant potential. It results in recurring thrombotic episodes. A decrease of protein S leads to a greater risk of thromboembolism.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Platelet Poor Plasma from a Blue Top Tube - 3.2% Na Citrate in a Plastic Vial


Transport And Storage

Unacceptable Ambient
Unacceptable Refrigerated
30 days Frozen


Collection Instructions

Draw blood in light blue-top tube containing 3.2% sodium citrate, and mix gently by inverting 3-4 times. 
Centrifuge 15 minutes at 1500 x g within 1 hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet
buffy layer and place into a plastic vial. 
Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). 
Freeze immediately and transport on dry ice.


Minimum Volume

0.5 mL Platelet Poor Plazma


Neonatal Volume

Clinical Interpretation

Reference Range:

70-140% of normal


Methodology:
  • Immunoturbidimetric
Clinical Significance

The congenital or acquired deficiency of protein S increases the risk for thromboembolism, owing to a decrease of blood anticoagulant potential. It results in recurring thrombotic episodes. A decrease of protein S leads to a greater risk of thromboembolism.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 6 days


Coding & Compliance

CDM

00910597


CPT Coding

85305


Medical Necessity Documentation

Recommended as outpatient testing only