Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Do not collect within 72 hours of a platelet transfusion. Transfused platelets will interfere with this assay
Specimen Requirements:
1.5 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:
Serum should be separated from red cells prior to shipping.
Minimum Volume:
0.5 mL Serum
Transport & Storage: Temperature/Stability:
Rejection Criteria:
Gross hemolysis • Serum separator tube
Reference Range:
Please refer to Interpretive Results
Critical Ranges:
Test Comments:
Methodology:
Solid Enzyme-Linked Immunosorbent Assay
Clinical Significance:
Platelet antibodies may be allo- or autoantibodies and may be directed to a wide range of antigenic "targets" carried on platelet cytoplasmic membranes. Serum platelet antibody test is optimized to identify the presence of platelet alloantibodies in the patient. Platelet alloantibodies are involved in several clinical situations such as: Immune mediated refractoriness to platelet transfusions usually due to antibodies to HLA class I and sometimes to antibodies specific to platelet antigens, neonatal alloimmune thrombocytopenia (NAIT), Posttransfusion purpura (PTP), which are usually associated with platelet-specific antibodies. This test is not recommended for the diagnosis of immune thrombocytopenia (ITP) or autoimmune thrombocytopenia. Tests that are optimized to detect antibodies bound to the platelets will be useful in these situations; cell-bound platelet antibody (Direct) test is strongly recommended instead (CBPAN/cell bound platelet auto-antibody screen, blood).
Documentation:
Platelet alloantibodies are involved in several clinical situations such as:
-Immune mediated refractoriness to platelet transfusions usually due to antibodies to HLA class I and sometimes to antibodies specific to platelet antigens.
-Neonatal alloimmune thrombocytopenia (NAIT)
-Posttransfusion purpura (PTP), which are usually associated with platelet-specific antibodies
This test is not recommended for the diagnosis of immune thrombocytopenia (ITP) or autoimmune thrombocytopenia. Tests that are optimized to detect antibodies bound to the platelets will be useful in these situations; cell-bound platelet antibody (Direct) test is strongly recommended instead (CBPAN / Cell Bound Platelet Auto-Antibody Screen, Blood).
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
2 to 4 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed:
Quest - Chantilly to Mayo Laboratory
PHL Test Code:
PLTAS
EPIC Test Code:
IMO5580
Send Out Test Code:
11484
Alternate Test Names:
Platelet Antibody Screen, Serum
Included Tests:
CPT Coding:
86022 (x5)