Drug Toxicology Benzodiazepines, with Confirmation, Oral Fluid

Last Modified: 3/25/2019 2:00:23 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  If donor's mouth is not empty immediately prior to collection, have subject rinse his/her mouth with water (up to 4 oz) and wait a minimum of 10 minutes before collecting a specimen.
Specimen Requirements:

3 mL oral fluid submitted in an Oral-Eze® collection device

Collection Instructions:  
Minimum Volume: 2.0 mL Oral Fluid
Transport & Storage: Temperature/Stability: 72 hours Ambient
7 days Refrigerated
30 days Frozen

Store refrigerated 2-8°C if not delivered to the testing site (Quest) within 48 hours of collection
Rejection Criteria: Specimens in a non-Oral Eze(R) collection; insufficient volume
Reference Range: Refer to Interpretive Results
Critical Ranges:  
Test Comments: If screening drug class result is equal to or greater than the cutoff, then confirmation testing will be performed at an additional charge (CPT code(s): 80346).
Methodology: Mass Spectrometry
Clinical Significance:

Oral fluid is composed of saliva, mixed with buccal and mucosal transudates, cellular debris, bacteria, and residue of ingested products. Oral fluid as a test matrix shows promise for detection of recent drug use, and a significant body of scientific literature documents aspects such as drug disposition and detection times. Researchers comparing the effectiveness of oral fluid testing with urine drug testing found a similar pattern and frequency of positive drug test results in the general workforce over the same general period. Similarly in pain clinics, the pattern of licit and illicit drugs and metabolites observed in oral fluid paralleled results reported for urine, with some minor differences in detection rates for different drug classes. In some cases, oral fluid testing may be an acceptable alternative or the only available matrix. As an ultra-filtrate of blood, however, it shares the limitations of a decreased window of detection versus conventional urine drug testing.

Custom Panel: No


Turn Around Time: 3 to 5 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: BENDO
EPIC Test Code: LAB2987
Send Out Test Code: 93979
Alternate Test Names: Drug Oral Benzodiazepines, Quant; DRUG ORAL, BENZODIAZEPINES, ; Drug Toxicology Benzodiazepines, Quantitative, Ora
Included Tests: Alprazolam, Chlordiazepoxide, Clonazepam, Diazepam, Flunitrazepam, Flurazepam, Lorazepam, Midazolam, Nordiazepam, Oxazepam, Temazepam, Triazolam
CPT Coding: 80307 (80346)

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