Islet Cell Autoantibodies Evaluation

Last Modified: 5/20/2020 2:46:49 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

2.0 mL Serum in a SST Gold Top Tube

Collection Instructions:  
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 48 hours Ambient
14 days Refrigerated (transport)
6 months Frozen
Reference Range:
Islet Cell Antibody Screen Negative
  Islet Cell Antibody Titer <1.25 JDF units
Critical Ranges:  
Test Comments:  If Islet Cell Antibody Screen is positive, then Islet Cell Antibody Titer will be performed at an additional charge (CPT code(s): 86341).
Methodology: Immunofluorescence Assay (IFA)
Clinical Significance: Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.
Custom Panel: No


Turn Around Time: 5 to 6 days
Days Performed: Monday, Tuesday, Wednesday, Thursday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: ISLE
EPIC Test Code: IMO208
Send Out Test Code: 36741
Alternate Test Names: Islet Cell Antibody Screen with Reflex to Titer
Included Tests: Islet Cell Autoantibodies CF; Islet Cell IgG Autoantibodies
CPT Coding: 86341 Reflex 86341

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