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Islet Cell Autoantibodies Evaluation
Last Modified:
8/21/2023 2:28:20 PM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
2.0 mL Serum in a SST
Gold Top Tube
Collection Instructions:
Minimum Volume:
0.5 mL Serum
Transport & Storage: Temperature/Stability:
48 hours Ambient
14 days Refrigerated (transport)
6 months Frozen
Reference Range:
Islet Cell Antibody Screen
Negative
Islet Cell Antibody Titer
<1.25 JDF units
Critical Ranges:
Test Comments:
If Islet Cell Antibody Screen is positive, then Islet Cell Antibody Titer will be performed at an additional charge (CPT code(s): 86341).
Methodology:
Immunofluorescence Assay (IFA)
Clinical Significance:
Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
5 to 6 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday
Sites Performed:
Quest - Chantilly to San Juan Capistrano
PHL Test Code:
ISLE
EPIC Test Code:
IMO208
Send Out Test Code:
36741
Alternate Test Names:
Islet Cell Antibody Screen with Reflex to Titer ; Islet Cell Eval
Included Tests:
Islet Cell Autoantibodies CF;
Islet Cell IgG Autoantibodies
CPT Coding:
86341 Reflex 86341
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