Gliadin Antibody Panel

Last Modified: 5/22/2019 2:44:55 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

1.0 mL Serum in a SST Gold Top Tube
Collection Instructions:  
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 48 hours Refrigerated
30 days Frozen

Specimen to be transported Refrigerated to PRMC within 48 hours of collection to be frozen by Immunology department to maintain specimen integrity until testing occurs. Do not transport Frozen.
Rejection Criteria: Microbially contaminated serum; gross hemolysis; gross lipemia
Reference Range:

Gliadin Antibody (IgG)

<20 Units Negative
≥20 Units Positive
Gliadin Antibody (IgA)
<20 Units Negative
≥20 Units Positive

Critical Ranges:  
Test Comments:  
Methodology: EIA
Clinical Significance: Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 7 days
Days Performed: Monday
Sites Performed: Parkview Regional Medical Center
PHL Test Code: GLAG
EPIC Test Code: IMO401
Alternate Test Names: Anti-Gliadin; Gliadin Antibody IgA & IgG
Included Tests: Gliadin IgA; Gliadin IgG
CPT Coding: 83516 x 2

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