Chronic Lymphocytic Leukemia Prognostic Panel without Karyotype

Last Modified: 5/13/2021 6:37:02 AM

Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial 
3.0 mL Whole Blood in a Lavender Top Tube - EDTA 
13.0 mL Whole Blood in a Green Top Tube - Na Heparin
Collection Instructions: Serum and EDTA whole blood and sodium heparin whole blood are required for this panel.
Minimum Volume: 0.5 mL serum, 1 mL EDTA WB, 3 mL Na WB
Transport & Storage: Temperature/Stability: 72 hours Ambient
Rejection Criteria: Hemolysis • Lipemia
Reference Range: Refer to Interpretive Results
Methodology: FC • FISH • PCR
Clinical Significance: Chronic lymphocytic leukemia is the most common leukemia in the Western World. The disease is chronic and most patients may not require therapy in the early stage of the disease. However, in some patients the disease can be aggressive and within a year the tumor mass may increase significantly imposing serious health problems to the patient. It is difficult to determine based on clinical presentation which patient will progress faster than the others. Therefore there is a need to use more accurate prognostic indicator to predict the clinical course of this disease. The recent advances in CLL therapy and biology made it possible to develop new tests for predicting clinical behavior, such as ZAP 70, IgVH,...However, each individual test has its limitation and a combination of these tests (panel) provide more accurate information.
Custom Panel: No


Turn Around Time: 8 to 10 days
Days Performed: Monday, Thursday
Sites Performed: Quest - Chantilly
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: 17312
Alternate Test Names: Chronic Lymphocytic Leukemia Prognostic Panel w/ou; Chronic Lymphocytic Leukemia Prognostic Panel with; CLL Panel, w/out Karyotype; CLL Prognostic Panel w/out Karyotype; CLL Prognostic Panel without Karyotype
Included Tests: Beta-2-Microglobulin; CD38+/CD19+;  Chronic Lymphocytic Leukemia, IgVH Mutation Status, Cell-based; FISH, B-Cell Chronic Lymphocytic Leukemia Panel; ZAP 70
CPT Coding: 00913333

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