Lactate Dehydrogenase Isoenzymes

Last Modified: 2/19/2020 12:55:32 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 2.0 mL Serum from a SST Gold Top Tube in a Plastic Vial
Collection Instructions:

Centrifuge serum specimens within 1 hour of collection, transfer serum to clean, plastic, screw-capped vial(s), and send at room temperature to the laboratory

Minimum Volume: 1.0 mL Serum
Transport & Storage: Temperature/Stability: 7 days Ambient
Rejection Criteria: Refrigerated; Frozen; Hemolysis; Icteric; Lipemic
Reference Range: Refer to Interpretive Results
Critical Ranges:  
Test Comments:  
Methodology: AE & KS
Clinical Significance: The LD isoenzyme pattern is useful to evaluate the source of elevated LD activity. LD isoenzyme elevation associations: LD1: germ cell tumors; LD1>LD2: renal or myocardial infarction, megaloblastic anemia, hemolysis; LD3: platelet destruction, reactive, lymphadenopathy, lymphoma, lymphocytosis, pulmonary infarction, pneumonia, advanced cancer, acute pancreatitis; LD4, LD5: various solid tumors; LD5: primary liver disease, liver anoxia, muscle injury or dystrophy; All forms: renal disease, carcinomatosis, collagen vascular vascular disease, overwhelming sepsis, DIC
Custom Panel: No


Turn Around Time: 2 to 3 days
Days Performed: Monday, Wednesday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 4411
Included Tests: LD Isoenzyme 1; LD Isoenzyme 2; LD Isoenzyme 3; LD Isoenzyme 4; LD Isoenzyme 5; Lactate Dehydrogenase Total
CPT Coding: 83615, 83625

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