Lactate Dehydrogenase Isoenzymes

Overview

  • EPIC Code:
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 4411
Included Tests

LD Isoenzyme 1; LD Isoenzyme 2; LD Isoenzyme 3; LD Isoenzyme 4; LD Isoenzyme 5; Lactate Dehydrogenase Total


Clinical Significance

The LD isoenzyme pattern is useful to evaluate the source of elevated LD activity. LD isoenzyme elevation associations: LD1: germ cell tumors; LD1>LD2: renal or myocardial infarction, megaloblastic anemia, hemolysis; LD3: platelet destruction, reactive, lymphadenopathy, lymphoma, lymphocytosis, pulmonary infarction, pneumonia, advanced cancer, acute pancreatitis; LD4, LD5: various solid tumors; LD5: primary liver disease, liver anoxia, muscle injury or dystrophy; All forms: renal disease, carcinomatosis, collagen vascular vascular disease, overwhelming sepsis, DIC


Specimen Collection & Preparation

Specimen Requirements

2.0 mL Serum from a SST Gold Top Tube in a Plastic Vial


Transport And Storage

7 days Ambient


Collection Instructions

Centrifuge serum specimens within 1 hour of collection, transfer serum to clean, plastic, screw-capped vial(s), and send at room temperature to the laboratory


Minimum Volume

1.0 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Please refer to interpretive results


Methodology:
  • Electrophoresis
  • Spectrophotometry (SP)
Clinical Significance

The LD isoenzyme pattern is useful to evaluate the source of elevated LD activity. LD isoenzyme elevation associations: LD1: germ cell tumors; LD1>LD2: renal or myocardial infarction, megaloblastic anemia, hemolysis; LD3: platelet destruction, reactive, lymphadenopathy, lymphoma, lymphocytosis, pulmonary infarction, pneumonia, advanced cancer, acute pancreatitis; LD4, LD5: various solid tumors; LD5: primary liver disease, liver anoxia, muscle injury or dystrophy; All forms: renal disease, carcinomatosis, collagen vascular vascular disease, overwhelming sepsis, DIC


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Wednesday
Friday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

2 to 3 days


Coding & Compliance

CDM

0091333


CPT Coding

83615, 83625