Estrone

Clinical Significance

Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women

Specimen Requirements

0.5 mL Serum from a Red Top Tube in a Plastic Vial

Transport And Storage

Room temperature: 72 hours
Refrigerated: 30 days (transport)
Frozen: 30 days

Collection Instructions

Order must and specimen must specify age and gender. 

Note: Norethindrone acetate/Norethisterone acetate is known to interfere with the measurement of estrone using the Quest Diagnostics LC-MS/MS method. This test should not be used to quantitate estrone in patients taking this drug.

Minimum Volume

0.25 mL Serum

Neonatal Volume

Reference Range:

Adult

Female

Follicular Stage

10-138

pg/mL

Luteal Stage

16-173

pg/mL

Postmenopausal

≤65

pg/mL

Male

≤68

pg/mL

 

Pediatric	Male (pg/mL)	Female (pg/mL)
Pre-pubertal (1-9 Years)	<10	≤34
10-11 Years	≤12	≤72
12-14 Years	≤28	≤75
15-17 Years	≤64	≤188

Test Comments:

*ERT= Estrogen Replacement Therapy

Methodology:

• Chromatography / Mass Spectrometry

Clinical Significance

Estrone is primarily derived from metabolism of androstenedione in peripheral tissues, especially adipose tissues. Individuals with obesity have increased conversion of androstenedione to Estrone leading to higher concentrations. In addition, an increase in the ratio of Estrone to Estradiol may be useful in assessing menopause in women

CDM

00917140

CPT Coding

82679