Insulin Autoantibody

Overview

  • EPIC Code:
  • IMO91
  • Soft Test Code:
  • INSA
  • Send Out Test Code:
  • 36178
Clinical Significance

Type 1 diabetes is characterized by a lymphocytic cell infiltrate of the pancreatic islets. Insulin Antibody is useful in assessing lower titers of autoantibody in patients with diabetes, detecting insulin autoantibody in patients who are ''prediabetic,'' and in detecting autoantibody in patients with other autoimmune disorders.

Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type I diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a Red Top Tube in a Plastic Vial


Transport And Storage

28 days Ambient 
28 days Refrigerated
28 days Frozen


Collection Instructions

Avoid Hemolysis and Lipemia


Minimum Volume

0.2 mL


Neonatal Volume

Clinical Interpretation

Reference Range:

Refer to Interpretive Results


Methodology:
  • Radioimmunoassay (RIA)
Clinical Significance

Type 1 diabetes is characterized by a lymphocytic cell infiltrate of the pancreatic islets. Insulin Antibody is useful in assessing lower titers of autoantibody in patients with diabetes, detecting insulin autoantibody in patients who are ''prediabetic,'' and in detecting autoantibody in patients with other autoimmune disorders.

Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type I diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Wednesday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

4 to 7 days


Coding & Compliance

CDM

00916337


CPT Coding

86337