Metanephrines, Fractionated, Free

Last Modified: 5/17/2019 3:44:12 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation: Overnight fasting is preferred. Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise before collection.
Specimen Requirements: 2.5 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial
Collection Instructions: 1. Collect whole blood specimen into a pre-chilled EDTA tube. 
2. Whole blood should be kept on wet ice until centrifuged (preferably at 4 degrees C) to separate the plasma within 2 hours of venipuncture.
3. Plasma should be transferred to Plastic Vial
4. Refrigerate
Minimum Volume: 1.5 mL
Transport & Storage: Temperature/Stability: 14 days Refrigerated (Preferred)
14 days Frozen
Reference Range: Metanephrines, LC/MS/MS: < or = 57 pg/mL
Normetanephrines, LC/MS/MS: < or = 148 pg/mL
Total Metanephrines, LC/MS/MS: < or = 205 pg/mL
Detection limit for MN, NM: 25 pg/mL
Detection limit for Total: 50 pg/mL

Critical Ranges:  
Test Comments:  
Methodology: LC/MS/MS
Clinical Significance: Normetanephrine (NM) and metanephrine (MN) are the extraneuronal catechol-o-methyl transferase (COMT) metabolites of the catecholamines norepinephrine and
epinephrine, respectively. Measure of plasma metanephrines is more sensitive (but may be less specific) than measurement of catecholamines for the detection of pheochromocytoma. Proper interpretation of results requires awareness of recent medication/drug history (e.g., antihypertensive agents, alcohol, cocaine) and other preanalytical factors (e.g., stress, severe congestive heart failure, myocardial infarction) that influence release of catecholamines and metanephrines.
Custom Panel: No


Turn Around Time: 5 to 8 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: METP
EPIC Test Code: LAB2589
Send Out Test Code: 19548 / 19548X
Alternate Test Names: Metanephrine, Plasma Fractionated
Included Tests: Metanephrine, Plasma; Normetanephrine, Plasma
CPT Coding: 83835

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