Methylmalonic Acid, Urine

Included Tests

Creatinine; Methylmalonic Acid

Clinical Significance

Methylmalonic Acid (MMA) is useful to diagnose and monitor Vitamin B₁₂ (cobalamin) deficiency, and to diagnose and monitor patients with methylmalonic acidemia

Specimen Requirements

1.7 mL Urine in a Plastic Container

Transport And Storage

4 days Ambient
12 days Refrigerated 
30 days Frozen (-20)
90 days Frozen (-70)

Collection Instructions

Unpreserved

Freeze

Minimum Volume

0.6 mL

Neonatal Volume

Reference Range:

Methylmalonic Acid, Urine

0.3-1.9 mmol/mol creat

Creatinine, Random Urine

0-6 Months	0.18-2.48 mmol/L
7-11 Months	0.18-2.74 mmol/L
1-2 Years	0.18-9.72 mmol/L
3-8 Years	0.18-11.49 mmol/L
9-12 Years	0.18-14.14 mmol/L
Adult	1.77-23.31 mmol/L

Methodology:

• Gas Chromatography / Tandem Mass Spectrometry (GC/MS/MS)

Clinical Significance

Methylmalonic Acid (MMA) is useful to diagnose and monitor Vitamin B₁₂ (cobalamin) deficiency, and to diagnose and monitor patients with methylmalonic acidemia

CPT Coding

82570, 83921