Clozapine & Norclozapine

Last Modified: 2/20/2019 12:42:09 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 2.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions: Do not collect in a Serum Separator Tube (SST or PST)
Minimum Volume: 1.0 mL
Transport & Storage: Temperature/Stability: 30 days Ambient
30 days Refrigerated
30 days Frozen

Avoid using glass material for long-term storage as drug adsorbs on the glass.
Reference Range: Clozapine: 25 - 400 ng/mL
The therapeutic response begins to appear at 100 ng/mL. Refractory schizophrenia appears to require a therapeutic concentration of at least 350 ng/mL (trough, at steady rate)

Norclozapine: 
25 - 400 ng/mL  (trough, at steady rate)
Critical Ranges:  
Test Comments:  
Methodology: LC-MS-MS
Clinical Significance: Clozapine is an antipsychotic agent. Peak clozapine concentrations are reached in 1-6 hours following oral dosage. Elimination half-life is 4-16 hours once steady state levels have been reached. Norclozapine has minimal therapeutic activity
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 6 days
Days Performed: Monday, Tuesday, Thursday, Friday
Sites Performed: Quest - Valencia
PHL Test Code: CLOZ
EPIC Test Code: LAB2562
Send Out Test Code: 4964
Alternate Test Names: Clozaril
Included Tests: Clozapine; Norclozapine
CPT Coding: 80159

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