Clozapine & Norclozapine

Last Modified: 8/15/2019 1:33:01 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 2.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:
Minimum Volume: 1.0 mL
Transport & Storage: Temperature/Stability: 30 days Ambient
30 days Refrigerated
30 days Frozen

Avoid using glass material for long-term storage as drug adsorbs on the glass.
Rejection Criteria: Serum Separator Tube (SST); Gel;
Reference Range:
Norclozapine 25-400 mcg/L
Clozapine See Laboratory Report
Critical Ranges:  
Test Comments:  
Methodology: LC-MS-MS
Clinical Significance: Clozapine is an antipsychotic agent. Peak clozapine concentrations are reached in 1-6 hours following oral dosage. Elimination half-life is 4-16 hours once steady state levels have been reached. Norclozapine has minimal therapeutic activity
Custom Panel: No


Turn Around Time: 3 to 6 days
Days Performed: Monday, Tuesday, Thursday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: CLOZ
EPIC Test Code: LAB2562
Send Out Test Code: 1769
Alternate Test Names: Clozapine and Norclozapine; Clozaril
Included Tests: Clozapine; Norclozapine
CPT Coding: 80159

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