Immunoglobulin A Subclasses

Last Modified: 7/14/2016 12:24:36 PM


Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions: Centrifuge within 1 hour of collection and immediately separate serum specimens from the cells
Minimum Volume: 1.0 mL Serum
Rejection Criteria: Received room temperature • No additive (royal blue-top)
Reference Range:
IgA1    
6-11 Months 1-115 mg/dL
1 Year 3-120 mg/dL
2 Years 7-132 mg/dL
3 Years 11-143 mg/dL
4-7 Years 23-175 mg/dL
8-11 Years 33-204 mg/dL
12-17 Years 47-249 mg/dL
≥18 Years 46-378 mg/dL
IgA2    
6-11 Months 0-19 mg/dL
1 Year 0-23 mg/dL
2 Years 1-23 mg/dL
3 Years 1-25 mg/dL
4-7 Years 2-33 mg/dL
8-11 Years 2-37 mg/dL
12-17 Years 4-50 mg/dL
≥18 Years 13-91 mg/dL
Total IgA    
6-11 Months 3-101 mg/dL
1 Year 6-112 mg/dL
2 Years 11-134 mg/dL
3 Years 16-155 mg/dL
4-7 Years 31-214 mg/dL
8-11 Years 43-268 mg/dL
12-17 Years 65-356 mg/dL
≥18 Years 81-463 mg/dL
Methodology: Nephelometry
Clinical Significance:

IgA1 constitutes approximately 80% of the circulating IgA.  IgA nephropathy is typically due to IgA1. IgA2 predominates in secretions of some mucosal surfaces. IgA2 concentrations may be useful as an index of mucosal pathology. Subclass deficiency is associated with anaphylactic transfusion reactions.

Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 1 to 2 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 3528
Alternate Test Names: IgA Subclasses
Included Tests: IgA1, IgA2, Total IgA
CPT Coding: 82784, 82787 x2

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