Metanephrines, Fractionated Urine

Included Tests

Creatinine; Metanephrines; Normetanephrines; Total Metanephrines; 

Clinical Significance

Useful in the evaluation of pheochromocytoma

Patient Preparation

If possible, patients should discontinue all drugs at least 1 week prior to collection. Medications that can interfere with the assay include: L-DOPA, Alpha-methyldopa (Aldomet), Buspirone, Codeine, Isoetharine, Isoproterenol, Mandelamine, Metoclopramide, Acetaminophen (high concentrations only), Labetalol, Catecholamine-containing drugs, MAO inhibitors, diuretics and vasodilators.

Specimen Requirements

5.0 mL Random Urine in a  Non-Sterile Yellow Capped Container

Transport And Storage

7 days (acidified) Ambient
8 days Refrigerated
30 days (acidified) Frozen (transport)

Collection Instructions

Record patients age on test request form and urine vial

Minimum Volume

1.5 mL Urine

Neonatal Volume

Reference Range:

Normetanephrine Random Urine: By Report ug/L
Metanephrine Random Urine: By Report ug/L
Creatinine, Random Urine: view ref range mg/dL
Normetanephrine/Creatinine Ratio: < 700 ug/g creat
Metanephrine/Creatinine Ratio: < 300 ug/g creat

Methodology:

• Kinetic Alkaline Picrate
• Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

Useful in the evaluation of pheochromocytoma

CDM

00913333

CPT Coding

82570, 83835