Hantavirus Antibody (IgG, IgM)

Overview

  • EPIC Code:
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 37547
Alternate Names
  • Hantavirus Renal and Pulmonary
Clinical Significance

Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre virus, which causes hantavirus pulmonary syndrome, a severe and possibly fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala viruses) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States. Sera are initially screened for IgG and IgM Antibody recognizing the nucleocapsid protein common to all hantaviruses. All equivocal and positive samples are further tested in confirmatory assays to detect antibody specific for Sin Nombre virus. A positive result in the screening ELISA but a negative result in a confirmatory assay may indicate reactivity to a hantavirus causing hemorrhagic fever with renal syndrome.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a Red Top Tube in a Plastic Vial


Transport And Storage

5 days Ambient (Transport)
14 days Refrigerated
30 days Frozen


Collection Instructions


Minimum Volume

0.25 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Hantavirus IgG <2.00
Hantavirus IgM <2.00


Methodology:
  • Enzyme Linked Immunosorbent Immunoassay (ELISA)
Clinical Significance

Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre virus, which causes hantavirus pulmonary syndrome, a severe and possibly fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala viruses) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States. Sera are initially screened for IgG and IgM Antibody recognizing the nucleocapsid protein common to all hantaviruses. All equivocal and positive samples are further tested in confirmatory assays to detect antibody specific for Sin Nombre virus. A positive result in the screening ELISA but a negative result in a confirmatory assay may indicate reactivity to a hantavirus causing hemorrhagic fever with renal syndrome.


Production Schedule

Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

2 to 4 days


Coding & Compliance

CDM

00913333


CPT Coding

86790 x 2