Chromogranin - A

Last Modified: 6/16/2022 7:52:04 AM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:
Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions: Treatment with proton-pump inhibitors or H2-receptor blockers will cause an increase in Chromogranin A concentrations
Allow blood to clot at room temperature. Centrifuge and separate the serum from the cells immediately. 
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 7 days Ambient
31 days Frozen (Transport)
Do not store refrigerated. 
Rejection Criteria: Unspun red-top tube • Serum separator tubes • Moderate to gross hemolysis • Moderate to grossly lipemic • Icteric
Reference Range: Adults: <311 ng/mL
Critical Ranges:  
Test Comments:
Methodology: Chromatography/Mass Spectometry
Clinical Significance: Chromogranin A, Rebaseline - Chromogranin-A (CgA) is an acidic glycoprotein expressed in the secretory granules of most normal and neoplastic neuroendocrine (NE) cell types, where it is released together with peptide hormones and biogenic amines. Neuroendocrine tumors (NETs) are a form of cancer that differ from other neoplasia in that they synthesize, store, and secrete peptides, e.g., CgA and amines. CgA is secreted from neuroendocrine-derived tumors including foregut, midgut and hindgut gastrointestinal NETs, pheochromocytomas, neuroblastomas, medullary thyroid carcinomas, some pituitary tumors, functioning and non-functioning pancreatic NETs. Significantly elevated CgA levels have been found in patients with other diseases, such as impaired renal function, untreated benign essential hypertension, gastritis, prostatic carcinoma, and hyperparathyroidism. The best-characterized circulating biomarker that identifies NETs in general is CgA. Monitoring blood CgA levels may effectively provide information that is helpful in delineating tumor burden and rate of tumor growth, predicting tumor response to therapy and providing some indication as to prognosis.
Custom Panel: No


Turn Around Time: 3 - 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: CHRGA
EPIC Test Code: IMO95
Send Out Test Code: 31911
Alternate Test Names: CgA; Chromogranin-A
Included Tests:  
CPT Coding: 86316

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