Complement C2

Last Modified: 5/11/2022 6:21:16 AM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 2.0 mL Serum from a Red Top Tube in a Plastic Vial
Minimum Volume: 0.1 mL Serum
Transport & Storage: Temperature/Stability: 12 days Ambient (Store)
12 days Refrigerated 
12 days Frozen

Freeze/thaw cycles stable x 3
Rejection Criteria: Excessive Hemolysis; plasma specimen
Reference Range: 1.4 - 3.3 mg/dL
Critical Ranges:  
Test Comments:  *Reference interval has been verified for all age groups including pediatrics (birth to 18yrs) and geriatrics

 Limitations:Results of this test are labeled for research purposes only by the assay's manufacturer. The performance characteristics of this assay have not been established by the manufacturer. The result should not be used for treatment or for diagnostic purposes without confirmation of the diagnosis by another medically established diagnostic product or procedure. The performance characteristics were determined by LabCorp
Methodology: Radial Immunodiffusion
Clinical Significance: Assess patients with hereditary deficiency of this component or acquired decrease in its level which may be seen due to hypercatabolism in hereditary angioneurotic edema, or consumption or loss as in vasculitides, glomerulonephritides, immune complex diseases. C2 deficiency is the most common complement deficiency (1 in 10,000) and is associated with SLE


Documentation: Additional Information: Deficiencies of C1 components, C2 and C4 are associated with rheumatic diseases, including lupus, vasculitis, and dermatomyositis. Some individuals with deficiency may have no evidence of disease. The most common complement deficiency is C2, which is a homozygous abnormality in 1 in 10,000 to 40,000 individuals, and is heterozygous in 1% to 2% of the general population. Patients with C2 deficiency and lupus often have negative or low titer ANA.
Custom Panel: No


Turn Around Time: 6 to 11 days
Sites Performed: Lab Corp
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: 161414
Alternate Test Names: C2 Complement
Included Tests: Quantitation of antigenic (immunologic) C2
CPT Coding: 86160

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