Cryoglobulin (% Cryocrit)

Last Modified: 7/18/2019 11:03:25 AM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:

Overnight Fasting is Required

Specimen Requirements:

3.0 mL Serum from Red Top Tube(s) in a Plastic Vial

Collection Instructions: Red Top after drawn must be full with 6 mL of fasting whole blood specimen in a red-top tube (no gel).

Allow serum sample to clot for one (1) hour in a 37° C (98.6°F) water bath, oven, incubator, or heat block. 
After clotting, centrifuge the specimen for 10 minutes at 1600 RCF(G) utilizing one of the 3 options below:
1) In a "warm" centrifuge at 37° C.
2) In a bench-top centrifuge placed in a "warm room" at 37° C.
3) At room temperature, in a bench-top centrifuge prewarmed by running it for 10 minutes at 1600 RCF(G).
After centrifuging, decant (gradually pour from one container into another, especially without disturbing the sediment) serum into a screw-cap vial.
Transport at room temperature.

Note: If the sample is not kept at 37°C during all processing steps, the cryoprecipitate if present can precipitate out of solution and be lost in the clot or during the centrifugation process and result in a false negative result.
Transport screw-capped vial at room temperature. 

After centrifuging, decant serum into a screw-capped vial.

No other tests can be added to the tube; cryocrit and cryoglobulin evaluation only
Minimum Volume: 2.0 mL Serum
Transport & Storage: Temperature/Stability: 72 hours Ambient after centrifugation process
Rejection Criteria: Gross hemolysis • Grossly Lipemic • icteric • Refrigerated • Frozen • Serum Separator Tube (SST®) • Gel
Reference Range: Cryoglobulin Qualitative: Negative
%Cryocrit: None Detected
Critical Ranges:  
Test Comments:  
Methodology: Visual inspection
Clinical Significance: The Cryocrit is primarily intended for following a patient with previously defined and quantitated Cryoglobulins. The Cryocrit may consist of Cryoglobulins, fibrin or mixtures of Cryoglobulins and fibrin.
Custom Panel: No


Turn Around Time: 4 to 5 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: CRYQ
EPIC Test Code: LAB2778
Send Out Test Code: 36562
Alternate Test Names: Cryoglobulin, Qualitative Reflex to %Cryocrit; Cryoglobulin, Quantitative
Included Tests:  
CPT Coding: 82595

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