Liver Fibrosis, FibroTest-ActiTest Panel

Included Tests

Alanine Aminotransferase (ALT); Alpha-2-Macroglobin; Apolipoprotein A1; Bilirubin, Total; Gamma Glutamyl Transferase (GGT); Haptoglobin; Fibrosis Score; Necroinflammat Act Score

Clinical Significance

FibroTest and ActiTest permit the non-invasive evaluation of Hepatitis C (or B) individuals for the presence of liver fibrosis and liver inflammation, respectively. The FibroTest and ActiTest scores are calculated based on patient age, gender and concentrations of serum of y-glutamyl transferase (GGT), total bilirubin (TB), a-2 macroglobulin, haptoglobin, apolipoprotein A1 and alanine aminotransferase (ActiTest). Fibrotest and ActiTest Scores, on a scale of 0.0 to 1.0, are assigned a Metavir scale indicating the level of fibrosis or inflammation present.

Patient Preparation

Overnight Fasting preferred

Specimen Requirements

3.5 mL Serum from a Red Top Tube

Transport And Storage

24 hours Ambient
72 hours Refrigerated
5 days Frozen (Transport)
28 days Frozen at -70°

Avoid freeze/thaw cycles

Collection Instructions

Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection)

Minimum Volume

2.0 mL Serum

Neonatal Volume

Reference Range:

Refer to Interprative Results

Methodology:

• Immunoassay
• Nephelometry
• Spectrophotometry (SP)

Clinical Significance

FibroTest and ActiTest permit the non-invasive evaluation of Hepatitis C (or B) individuals for the presence of liver fibrosis and liver inflammation, respectively. The FibroTest and ActiTest scores are calculated based on patient age, gender and concentrations of serum of y-glutamyl transferase (GGT), total bilirubin (TB), a-2 macroglobulin, haptoglobin, apolipoprotein A1 and alanine aminotransferase (ActiTest). Fibrotest and ActiTest Scores, on a scale of 0.0 to 1.0, are assigned a Metavir scale indicating the level of fibrosis or inflammation present.

CDM

00919621

CPT Coding

81596

Medical Necessity May Apply