HLA DQ2/DQ8

Overview

  • EPIC Code:
  • LAB2717
  • Soft Test Code:
  • HDQ28
  • Send Out Test Code:
  • 6260
Alternate Names
  • Celiac Genetics
  • HLA-DQ2
  • HLA-DQ8 Haplotypes
Clinical Significance

Analyzes a patient's genetic profile for genes specifically associated with celiac disease.  Advanced high-resolution DNA probe analysis of HLA-DQ haplotypes allow for disease risk stratification depending upon which HLA genes are detected.  Also, testing can predict with a 95% to 100% negative predictive value (NPV) that the patient will not develop celiac disease if HLA-DQ2 and HLA-DQ8 haplotypes are not present.


Specimen Collection & Preparation

Specimen Requirements

5.0 mL Whole Blood in a Lavender Top Tube - EDTA


Transport And Storage

7 days Ambient (preferred)
30 days Refrigerated


Collection Instructions

 Must submit the collection tube, do not pour into another tube


Minimum Volume

5.0 mL Whole Blood EDTA


Neonatal Volume

Clinical Interpretation

Reference Range:

 

HLA-DQ2/DQ8: Not Detected

 


Test Comments:

(Allele frequency varies by ethnic population)


Methodology:
  • Multiple - Based on Individual Components
Clinical Significance

Analyzes a patient's genetic profile for genes specifically associated with celiac disease.  Advanced high-resolution DNA probe analysis of HLA-DQ haplotypes allow for disease risk stratification depending upon which HLA genes are detected.  Also, testing can predict with a 95% to 100% negative predictive value (NPV) that the patient will not develop celiac disease if HLA-DQ2 and HLA-DQ8 haplotypes are not present.


Production Schedule

Sites Performed
  • Prometheus
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

5 to 8 days


Coding & Compliance

CDM

00913008


CPT Coding

81382 x 2