D-Dimer, Quantitative

Last Modified: 2/20/2019 4:18:01 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 1.0 mL Platelet Poor Plasma from a full Blue Top Tube - 3.2% Buffered Sodium Citrate
Collection Instructions: Specimens must be filled appropriately see this example

Correct ratio of Blood to Citrate is critical (9:1). Specimens must be filled within +/- 10% of stated volume.

Specimens collected from a Heparinized Patient must be spun within 1 hour of collection

If a Blue Top Tube is collected utilizing a butterfly, a Blue Discard Tube must be drawn first to remove air from the line. If this is not done, the Blue Top Tube will not be filled properly due to the vacuum in tube and a redraw will be required

Note: Collection of blood for coagulation testing through intravenous lines that have been previously flushed with heparin should be avoided, if possible. 
If the blood must be drawn through an indwelling catheter, possible heparin contamination and specimen dilution should be considered. 
When obtaining specimsn from indwelling lines that may contain heparin, the line should be flushed with 5mL of saline, and the first 5 mL of blood or 6-times the line volume
(dead space volume of the catheter) be drawn off and discarded before the coagulation tube is filled. For those samples collected from a normal saline lock (capped off venous port) twice the dead space volume of the catheter and extension set should be discarded.

Minimum Volume: 1.8 mL PP Plasma from a Clear Blue Top Tube
Transport & Storage: Temperature/Stability: 4 hours Ambient 

24 hours Refrigerated

Rejection Criteria: Frozen in Frost Free Freezer; over or under filled tubes; 3.8% Sodium Citrate
Reference Range: <0.50 mg/L (FEU)
Critical Ranges:  
Test Comments:

In excluding deep vein thrombosis (DVT) and pulmonary (PE): In a non-high clinical probability population, using a cutoff of 0.5 mg/L FEU, a normal (<0.5 mg/L FEU) result excludes deep vein thrombosis (DVT) and pulmonary (PE) effectively. (Negative predictive value is 96-100% and 97.5-100% respectively)

In detecting DVT and PE: using a cutoff of 0.5 mg/L FEU, the sensitivity is 96-100% and 93.3-100% respectively and the specificity is 34.5% and 39.6% respectively.
Methodology: Immuno Assay
Clinical Significance: Quantitation of cross-linked fibrin degradation products in human plasma
Custom Panel: No


Stat Eligible: Yes
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Parkview Hospital Randallia, Parkview Huntington, Parkview LaGrange, Parkview Noble, Parkview Regional Medical Center, Parkview Wabash, Parkview Warsaw , Parkview Whitley
PHL Test Code: DIMQ2
EPIC Test Code: LAB313
Alternate Test Names: Dimer; FDP; Fibrin Split Products; Fibrinogen Degradation Products; FSP
Included Tests:  
CPT Coding: 85379

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