Itraconazole

Overview

  • EPIC Code:
  • LAB3196
  • Soft Test Code:
  • ITRA
  • Send Out Test Code:
  • 94092
Alternate Names
  • Itraconazole, HPLC
  • Itraconazole, Hydroxyitraconazole
  • Itraconazole, Serum/Plasma
Included Tests

Itraconazole; OH-Intraconazole


Clinical Significance

 Itraconazole - The antifungal drug itraconazole is active in the treatment of aspergillosis, blastomycosis, histoplasmosis, sporotrichosis, and onychomycosis. It is a protein-bound drug and thus has negligible CSF penetration. It may also be utilized in the treatment of systemic candidiasis and cryptococcosis, especially when other drugs are contraindicated or ineffective. The chronic nature of fungal infections demands constant monitoring of itraconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted.


Specimen Collection & Preparation

Specimen Requirements

2.0 mL Serum from a Red Top Tube in a Plastic Vial


Transport And Storage

72 hours Ambient
14 days Refrigerated (Transport - cold packs)
30 days Frozen



Collection Instructions


Minimum Volume

1.0 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Itraconazole (trough) localized infection: greater than 0.5 mcg/mL

Itraconazole (trough) systemic infection: greater than 1.0 mcg/mL

The total of Itraconazole and its active metabolite, hydroxyl-itraconazole, is 1-4 mcg/mL


Methodology:
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)
Clinical Significance

 Itraconazole - The antifungal drug itraconazole is active in the treatment of aspergillosis, blastomycosis, histoplasmosis, sporotrichosis, and onychomycosis. It is a protein-bound drug and thus has negligible CSF penetration. It may also be utilized in the treatment of systemic candidiasis and cryptococcosis, especially when other drugs are contraindicated or ineffective. The chronic nature of fungal infections demands constant monitoring of itraconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted.


Production Schedule

Sites Performed
  • Quest - Chantilly to Quest Lewisville
Days Performed
Tuesday
Thursday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

4 to 7 days


Coding & Compliance

CDM

00917600


CPT Coding

80299 - 80189 1/1/21