Last Modified: 3/3/2021 12:25:03 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 2.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:  
Minimum Volume: 1.0 mL Serum
Transport & Storage: Temperature/Stability: 72 hours Ambient
14 days Refrigerated (Transport - cold packs)
30 days Frozen

Rejection Criteria: Serum separator tubes are not acceptable; other body fluids; other specimen types
Reference Range:

Itraconazole (trough) localized infection: greater than 0.5 mcg/mL

Itraconazole (trough) systemic infection: greater than 1.0 mcg/mL

The total of Itraconazole and its active metabolite, hydroxyl-itraconazole, is 1-4 mcg/mL

Critical Ranges:  
Test Comments:  
Methodology: Liquid Chromatography/Tandem Mass Spectrometry
Clinical Significance:  Itraconazole - The antifungal drug itraconazole is active in the treatment of aspergillosis, blastomycosis, histoplasmosis, sporotrichosis, and onychomycosis. It is a protein-bound drug and thus has negligible CSF penetration. It may also be utilized in the treatment of systemic candidiasis and cryptococcosis, especially when other drugs are contraindicated or ineffective. The chronic nature of fungal infections demands constant monitoring of itraconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted.
Custom Panel: No


Turn Around Time: 4 to 7 days
Days Performed: Tuesday, Thursday, Saturday
Sites Performed: Quest - Valencia
PHL Test Code: ITRA
EPIC Test Code: LAB3196
Send Out Test Code: 94092
Alternate Test Names: Itraconazole, HPLC; Itraconazole, Hydroxyitraconazole
Included Tests: Itraconazole; OH-Intraconazole
CPT Coding: 80299 - 80189 1/1/21

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