HIV-1 Resistance, Proviral DNA (RTI, PI, Integrase Inhibitors)

Last Modified: 3/8/2018 2:26:59 PM

Specimen Requirements: 2.0 mL Whole Blood in a Lavender Top Tube - EDTA
Minimum Volume: 0.6 mL Whole Blood
Transport & Storage: Temperature/Stability: 7 days Ambient (Transport)
7 days Refrigerated
28 days Frozen
Reference Range: Refer to Interpretive Results
Test Comments: This test utilizes PCR and next generation (ultra-deep) sequencing of proviral DNA to detect drug resistance mutations in the HIV-1 protease, reverse transcriptase and integrase genes. This information will assist clinicians considering a modification of the treatment regimens for virologically suppressed patients or for patients with a low viral load for whom an RNA resistance test was not successful.
Methodology: Polymerase Chain Reaction (PCR) • Next Generation (ultra-deep) Sequencing
Clinical Significance: Guide change of antiretroviral therapy for HIV-1-infected and virologically suppressed patients
Custom Panel: No


Turn Around Time: 5 to 6 days
Days Performed: Tuesday, Saturday
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 94807
Alternate Test Names: Archived DNA; Archived resistance; Cell-associated Viral DNA; ndetected viral load; Resistance Analysis
CPT Coding: 87900; 87901; 87906

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