EGFR Mutation Analysis

Clinical Significance

EGFR mutation analysis is recommended in non-small cell lung carcinoma (NSCLC) to detect mutations (commonly L858R and exon 19 deletions) associated with increased sensitivity to EGFR tyrosine kinase inhibitors. Detection of TKI resistance mutations such as T790M in patients being treated with a TKI is useful for planning alternate treatment

Specimen Requirements

FFPE tissue: Paraffin block

Transport And Storage

 Refrigerate, and use cold pack for transport, cold pack should not be in direct contact with specimen.

Collection Instructions

Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.

Minimum Volume

Neonatal Volume

Reference Range:

Refer to Interpretive Results

Methodology:

• Molecular

Clinical Significance

EGFR mutation analysis is recommended in non-small cell lung carcinoma (NSCLC) to detect mutations (commonly L858R and exon 19 deletions) associated with increased sensitivity to EGFR tyrosine kinase inhibitors. Detection of TKI resistance mutations such as T790M in patients being treated with a TKI is useful for planning alternate treatment

CDM

00918077

CPT Coding

81235