BCR-ABL1 Gene Rearrangement, Quantitative, PCR

Last Modified: 2/13/2019 12:49:54 PM


  Medicare Medical Necessity Restrictions May Apply
Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

6.0 mL Whole Blood in a Lavender Top Tube - EDTA

Collection Instructions:

After collection of the sample, draw date and time, as well as sample type, must be written on the tube and included as requested information.

Minimum Volume: 4.0 mL Whole Blood
Transport & Storage: Temperature/Stability: 72 hours Ambient
72 hours Refrigerated

Ship sample immediately due to the short stability of 72 hours.
Reference Range:

BCR-ABL1/ABL1 %: 0.000
BCR-ABL1/ABL1 % (IS): 0.000
Interpretation: See Laboratory Report

Critical Ranges:  
Test Comments:  
Methodology: Quantitative Real-Time Polymerase Chain Reaction (PCR)
Clinical Significance: This reverse-transcription PCR-based assay detects the BCR-ABL1 transcript produced by the t(9;22) chromosomal translocation associated with chronic myelogenous leukemia (CML) and a subset of lymphoblastic leukemias. For the P190 transcript associated with the minor t(9;22) breakpoint in lymphoblastic leukemia, BCR-ABL1 transcript levels are expressed as a percent ratio of BCR-ABL1 to the normalizing ABL1 transcript. For the P210 transcript associated with CML, quantitation is further adjusted to the international scale (IS) to allow comparison with other IS-compliant BCR-ABL1 assays. Optimal therapy in CML is associated with transcript levels below the major molecular response (MMR) milestone indicated by a BCR-ABL1/ABL1 % (IS) below 0.1.
Documentation: CPT Coding
If P190 transcript expression was previously documented, only P190 BCR-ABL1 will be performed (CPT code(s): 81207).
If P210 transcript expression was previously documented, only P210 BCR-ABL1 will be performed (CPT code(s): 81206).
If no prior positive is documented, P190 BCR-ABL1 and P210 BCR-ABL1 will be performed (CPT code(s): 81206, 81207).
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 5 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: BCRP
EPIC Test Code: LAB2879
Send Out Test Code: 91065
Alternate Test Names: BCR ABL PCR; BCR/ABL for CML; bcr/abl Gene Rearrangement, QN,Pl-based,Leumeta(R); BCR/ABL Major (p210; b2a2 or b3a2); P190 BCR-ABL transcript; P210 BCR-ABL transcript; Philadelphia Chromosome; Quantitative BCR/ABL, t(9;22); t(9;22)
Included Tests:  
CPT Coding: 81206, 81207

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