HLA - B27 Antigen

Overview

  • EPIC Code:
  • IMO427
  • Soft Test Code:
  • HLAB
  • Send Out Test Code:
  • 528
Alternate Names
  • Ankylosing Spondylitis
  • HLA-B27
Clinical Significance

HLA-B27 is found in 90% of patients with ankylosing spondylitis and 80% in Reiter's disease. Ankylosing spondylitis affects 1 in 1000 caucasians. Ankylosing spondylitis is 10 times more common among individuals with HLA-B27 compared to individuals without this antigen.


Specimen Collection & Preparation

Specimen Requirements

5.0 mL Whole Blood in a Green Top Tube - Na Heparin


Transport And Storage

7 days Ambient (preferred)
5 days Refrigerated


Collection Instructions

 


Minimum Volume

2.0 mL


Neonatal Volume

Clinical Interpretation

Reference Range:

Frequency of occurrence 
Caucasians: 6-8%
African Americans: 3-4%
Asians: 1%


Methodology:
  • Flow Cytometry (FC)
Clinical Significance

HLA-B27 is found in 90% of patients with ankylosing spondylitis and 80% in Reiter's disease. Ankylosing spondylitis affects 1 in 1000 caucasians. Ankylosing spondylitis is 10 times more common among individuals with HLA-B27 compared to individuals without this antigen.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 5 days


Coding & Compliance

CDM

01425136


CPT Coding

86812