Neuron Specific Enolase

Overview

  • EPIC Code:
  • LAB2639
  • Soft Test Code:
  • Send Out Test Code:
  • 34476
Alternate Names
  • ENOL1
  • Neuron Specific Enolase (NSE), Serum
  • Neuron-Spec Enolase
Clinical Significance

Elevated levels of serum NSE are reported in patients with small cell carcinomas primarily of lung origin. Patients with neuroblastomas may also have high levels of NSE. Serum NSE can be used to monitor recurrence or progression of tumor in these cancer patients. Daily serial monitoring of serum NSE may also be used in comatose patients to assess neuronal damage. High NSE levels in comatose patients at 24hr and 48hr post cardio-pulmonary resusitation have been associated with poor outcome. Hemolysis can cause false positive results


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum in a SST Gold Top Tube


Transport And Storage

7 days Ambient
7 days Refrigerated
30 days Frozen


Collection Instructions

 


Minimum Volume

0.3 mL


Neonatal Volume

Clinical Interpretation

Reference Range:

< or = 14 ng/mL


Methodology:
  • Enzyme Immunoassay (EIA)
Clinical Significance

Elevated levels of serum NSE are reported in patients with small cell carcinomas primarily of lung origin. Patients with neuroblastomas may also have high levels of NSE. Serum NSE can be used to monitor recurrence or progression of tumor in these cancer patients. Daily serial monitoring of serum NSE may also be used in comatose patients to assess neuronal damage. High NSE levels in comatose patients at 24hr and 48hr post cardio-pulmonary resusitation have been associated with poor outcome. Hemolysis can cause false positive results


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Thursday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 5 days


Coding & Compliance

CDM

00916316


CPT Coding

86316