Last Modified:
2/10/2022 7:15:48 AM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
5.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:
Transport & Storage: Temperature/Stability:
7 days Ambient
7 days Refrigerated
7 days Frozen
Rejection Criteria:
Serum Separator Tube (SST); Gel
Reference Range:
| Oxycodone |
10-100 ng/mL |
| Oxymorphone |
Not established |
Critical Ranges:
Test Comments:
Methodology:
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Clinical Significance:
For therapeutic drug monitoring of oxycodone (Oxycontin®, Percocet®, Percodan®). Oxycodone is a semisynthetic opioid analgesic. Steady state concentration is reached in 24-36 hours after initiation of therapy.
Elimination half-life of oxycodone is 4.5 hours for controlled release and 3.2 hours for immediate release formulations. Peak plasma concentration of oxycodone is 11, 21, 29, 39, 99, or 156 ng/mL after a single oral dose of 10, 20, 40, 80, or 160 mg, respectively. Oxymorphone is a minor but active metabolite of Oxycodone that is present at lower concentration in the circulation. Therapeutic concentrations for oxymorphone have not been established.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
3 days
Days Performed:
Tuesday, Thursday, Saturday
Sites Performed:
Quest - Chantilly
PHL Test Code:
MSOT
EPIC Test Code:
MISC
Send Out Test Code:
18885
Alternate Test Names:
Percocet®
Included Tests:
Oxycodone, Oxymorphone
CPT Coding:
80365 (HCPCS: G0480)
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