Hepatitis E Antibodies IgG, IgM

Last Modified: 2/15/2019 7:11:36 AM


Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial
Minimum Volume: 0.2 mL Serum
Transport & Storage: Temperature/Stability: 7 days Ambient
14 days Refrigerated
30 days Frozen
Rejection Criteria: Serum Separator Tube (SST); Gel
Reference Range: Not detected

Hepatitis E Virus (HEV) is a major cause of enteric non-A hepatitis worldwide. Both HEV IgM and IgG are typically detected within one month after infection; IgM persists for about two months, whereas IgG levels persist for months to years after recovery. Approximately 20% of the U.S. population is positive for HEV IgG, indicating that HEV exposure is more common than previously thought.
Methodology: Enzyme Linked Immunosorbent Assay (ELISA)
Clinical Significance:

Hepatitis E virus (HEV) is the major etiologic agent of enterically transmiited non-A, non-B hepatitis worldwide and has a high case-fatality rate in pregnant women. Both IgM and IgG antibody to HEV (anti-HEV) are produced following infection. The titer of IgM anti-HEV declines rapidly during early convalescence; IgG anti-HEV persists and appears to provide at least short-term protection against disease.

Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 6 days
Days Performed: Tuesday, Friday
Sites Performed: Quest Diagnostic Infectious Disease
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 15085
Alternate Test Names: Hepatitis E Abs ; Hepatitis E Antibodies
CPT Coding: 86790 x 2

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