Cholinesterase, RBC and Plasma

Last Modified: 5/2/2022 1:45:48 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

5.0 mL Whole Blood in Lavender Top Tube EDTA unspun
1.0 mL Plasma from a Second Lavender Top Tube - EDTA in a Plastic Vial

Collection Instructions: 1. Draw two Lavender Top Tubes. 
2. Spin one tube to separate plasma. 
3. Pour EDTA Plasma into plastic aliquot vial and refrigerate until shipping. 
4. Send both the Whole Blood Lavendar Top Tube - EDTA and the Vial of EDTA Plasma from the second Lavendar Top Tube.

Do not send Packed Cells. 

Plasma cholinestrase results, as well as calculated RBC cholinesterase results, are not accurate if plasma is not separated from the RBSs in a timely manner. 

Receipt of only a single tue of whole blood is unacceptable. 

Avoid Hemolysis & Lipemia
Minimum Volume: 4.0 mL EDTA Whole Blood; 0.5 mL EDTA Plasma
Transport & Storage: Temperature/Stability: 7 days Refrigerated
Rejection Criteria: Ambient; Frozen; hemolyzed; lipemic; Only one specimen sent
Reference Range: RBC
9572 - 15031 IU/L

Male: 3334 - 7031 IU/L
Female: 2504 - 6297 IU/L
Critical Ranges:  
Test Comments:  
Methodology: Kinetic Spectrophotometric
Clinical Significance: True cholinesterase (RBC and plasma) activity is decreased in individuals with exposure to organophosphorous insecticides. True cholinesterase, found in erythrocytes and nerve tissue, is responsible for inactivating acetylcholinesterase at nerve endings. With decreased enzyme activity, patients may display a range of nervous system dysfunction. Analysis of RBC and serum or plasma activity is useful in monitoring exposure and recovery.

To assess both acute and chronic exposure to organophosphates
Custom Panel: No


Turn Around Time: 2 to 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: CHRP
EPIC Test Code: LAB2532
Send Out Test Code: 338
Alternate Test Names: Acetylcholinesterase Panel; Cholinesterase Profile
Included Tests:

Cholinesterase Plasma; Cholinesterase RBC

CPT Coding: 82480, 82482

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