Last Modified:
11/13/2023 10:59:26 AM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
5.0 mL Whole Blood in a Lavender Top Tube - EDTA
Collection Instructions:
Optimum time to collect sample is 1 hour before dose (trough collecton)
Minimum Volume:
2.0 mL Whole Blood
Transport & Storage: Temperature/Stability:
7 days Ambient
6 days Refrigerated
Rejection Criteria:
Frozen Specimen; Clotted Specimen
Reference Range:
No definitive therapeutic or toxic ranges have been established. Opitmal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.
Critical Ranges:
Test Comments:
The following trough ranges are suggested guidelines:
| Kidney Transplantation |
100-200 mcg/L |
| Other Organ Transplant |
200-300 mcg/L |
Methodology:
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Clinical Significance:
Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
1 to 2 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed:
Quest - Chantilly
PHL Test Code:
CYCS
EPIC Test Code:
LAB7000
Send Out Test Code:
15220
Alternate Test Names:
Cyclosporine A Trough
Included Tests:
CPT Coding:
80158
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