Cyclosporine

Last Modified: 2/20/2019 4:12:13 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:  5.0 mL Whole Blood in a Lavender Top Tube - EDTA
Collection Instructions:  Optimum time to collect sample is 1 hour before dose (trough collecton)
Minimum Volume: 2.0 mL Whole Blood
Transport & Storage: Temperature/Stability: 7 days Ambient 
6 days Refrigerated
Rejection Criteria: Frozen Specimen; Clotted Specimen
Reference Range: No definitive therapeutic or toxic ranges have been established. Opitmal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.
Critical Ranges:  
Test Comments: The following trough ranges are suggested guidelines:
Kidney Transplantation 100-200 mcg/L
Other Organ Transplant 200-300 mcg/L
Methodology: Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Clinical Significance:  Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 1 to 2 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: CYCS
EPIC Test Code: LAB7000
Send Out Test Code: 15220
Alternate Test Names: Cyclosporine A Trough
Included Tests:  
CPT Coding: 80158

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