The presence of E6/E7 messenger RNA from 14 high risk HPV types indicates incorporation of HPV DNA into the host cells. Proteins expressed from E6-E7 polycistronic mRNA alter cellular p53 and retinoblastoma protein functions, leading to disruption of cell-cycle check points and cell genome instability. This information, together with the physician’s assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management.
ThinPrep® vial with a minimum of 1.5 mL Preservcyt® fluid remaining after cytology is performed, or transfer 1 mL of Preservcyt® fluid into APTIMA® specimen transfer tube (green label)
30 days Ambient (transport)
90 days Refrigerated
Please note: For clients performing their own cytology (pap testing), who choose to send HPV mRNA testing to Quest Diagnostics, the preferred specimen requirement steps should be adhered to.
1.) Collect cervical specimens in ThinPrep® Pap Test vials containing PreservCyt® Solution with broom-type or cytobrush/spatula collection devices according to the manufacturer's instructions.
2.) Alternatively, 1 mL PreserCyt® can be aliquoted pre-cytology or post-cytology..
Not Detected
This test was performed using the APTIMA® HPV Assay (Gen-Probe Inc.).
The presence of E6/E7 messenger RNA from 14 high risk HPV types indicates incorporation of HPV DNA into the host cells. Proteins expressed from E6-E7 polycistronic mRNA alter cellular p53 and retinoblastoma protein functions, leading to disruption of cell-cycle check points and cell genome instability. This information, together with the physician’s assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management.
3 to 6 days
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