An aid to evaluate patients suspected of having systemic mastocytosis using random urine collections
5.0 mL frozen random Urine collection in a Plastic Container
24 hours Ambient
7 days Refrigerated
30 days Frozen (preferred)
2.0 mL Urine
< or =104 pg/mg creatinine
Elevated urinary leukotriene E4 (LTE4) concentrations greater than 104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.
Urinary LTE4 may be used together with serum tryptase, urinary 2,3-dinor 11 beta-prostaglandin F2 alpha, and/or urinary N-methyl histamine.
An aid to evaluate patients suspected of having systemic mastocytosis using random urine collections
2 to 6 days
00913334
82542; 82570