Leukotriene E4, Urine

Last Modified: 3/2/2022 6:29:50 AM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

5.0 mL frozen random Urine collection in a Plastic Container
Minimum Volume: 2.0 mL Urine
Transport & Storage: Temperature/Stability: 24 hours Ambient
7 days Refrigerated 
30 days Frozen (preferred)
Reference Range: < or =104 pg/mg creatinine
Critical Ranges:  
Test Comments:

Elevated urinary leukotriene E4 (LTE4) concentrations greater than 104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.

 Urinary LTE4 may be used together with serum tryptase, urinary 2,3-dinor 11 beta-prostaglandin F2 alpha, and/or urinary N-methyl histamine.
Methodology: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) & Enzymatic Colorimetric Assay
Clinical Significance: An aid to evaluate patients suspected of having systemic mastocytosis using random urine collections
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 2 to 6 days
Days Performed: Tuesday, Friday
Sites Performed: Mayo Laboratory
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: LTE4R
Alternate Test Names: Cysteinyl Leukotriene; Leukotriene E4, Random, Urine; Leukotriene E4, U; LTE4; Mast Cell Activation Syndrome; Mastocytosis; Systemic Mast Cell Activation
Included Tests:  
CPT Coding: 82542; 82542

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