Leukotriene E4, Urine

Last Modified: 11/15/2019 6:39:08 AM

Specimen Requirements:

4.0 mL random Urine collection in a Plastic Container

Collection Instructions: Refrigerate specimen after collection and send specimen refrigerated or frozen; do not add any preservative
Minimum Volume: 1.0 mL Urine
Transport & Storage: Temperature/Stability: 24 hours Ambient
7 days Refrigerated (preferred)
30 days Frozen
Reference Range: < or =104 pg/mg creatinine
Test Comments: Elevated urinary leukotriene E4 (LTE4) concentrations above 104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.
Urinary LTE4 may be used together with serum tryptase, urinary 2,3-dinor 11 beta-prostaglandin F2 alpha, and urinary N-methylhistamine.
LTE4 values of 166 pg/mg creatinine were 89% specific for aspirin sensitivity among patients with respiratory diagnoses.


Methodology: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) & Enzymatic Colorimetric Assay
Clinical Significance: Evaluating patients suspected of having systemic mastocytosis 

Identification of aspirin sensitivity in patient respiratory diagnoses
Custom Panel: No


Turn Around Time: 2 to 6 days
Days Performed: Tuesday, Friday
Sites Performed: Mayo Laboratory
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: LTE4
Alternate Test Names: Cysteinyl Leukotriene; Leukotriene E4, U; LTE4; Mast Cell Activation Syndrome; Mastocytosis; Systemic Mast Cell Activation
CPT Coding: 82542

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