Leukotriene E4, Urine

Overview

  • EPIC Code:
  • MISC
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • LTE4R
Alternate Names
  • Cysteinyl Leukotriene
  • Leukotriene E4, Random, Urine
  • Leukotriene E4, U
  • LTE4
  • Mast Cell Activation Syndrome
  • Mastocytosis
  • Systemic Mast Cell Activation
Clinical Significance

An aid to evaluate patients suspected of having systemic mastocytosis using random urine collections


Specimen Collection & Preparation

Specimen Requirements

5.0 mL frozen random Urine collection in a Plastic Container


Transport And Storage

24 hours Ambient
7 days Refrigerated 
30 days Frozen (preferred)


Collection Instructions


Minimum Volume

2.0 mL Urine


Neonatal Volume

Clinical Interpretation

Reference Range:

< or =104 pg/mg creatinine


Test Comments:

Elevated urinary leukotriene E4 (LTE4) concentrations greater than 104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.

 Urinary LTE4 may be used together with serum tryptase, urinary 2,3-dinor 11 beta-prostaglandin F2 alpha, and/or urinary N-methyl histamine.


Methodology:
  • Enzymatic Colorimetric Assay
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)
Clinical Significance

An aid to evaluate patients suspected of having systemic mastocytosis using random urine collections


Production Schedule

Sites Performed
  • Mayo Laboratory
Days Performed
Tuesday
Friday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

2 to 6 days


Coding & Compliance

CDM

00913334


CPT Coding

82542; 82570