ANAlyzeR™ ANA, IFA with Reflex Titer/Pattern, Systemic Autoimmune Panel 1

Last Modified: 8/30/2021 3:04:41 PM

Patient Preparation: Overnight fasting is preferred
Specimen Requirements:

9.0 mL Serum from a Red Top Tube(s) in a Plastic Vial

Minimum Volume: 6.0 mL Serum
Transport & Storage: Temperature/Stability: 7 days Refrigerated (transport)
30 days Frozen
Rejection Criteria: Gross hemolysis, grossly lipemic, grossly icteric, ambient
Reference Range: Refer to Interpretive Results
Test Comments:
  • If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039). 
  • If the DNA (ds) Antibody Screen is positive, then DNA (ds) Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Methodology: Multiple - See Individual Tests
Clinical Significance: This panel is used to aid in the screening and diagnosis of autoimmune disorders such as Mixed Connective Tissue Diseases, Systemic Lupus Erythematosus, Sjogren Syndrome, CREST syndrome (calcinosis, Raynaud's syndrome, esophageal dysfunction, sclerodactyly and telangiectasia), Idiopathic Raynaud's Syndrome, drug induced lupus, ANA-negative lupus, diffuse scleroderma, etc., also including autoimmune thyroiditis, rheumatoid arthritis, and atypical autoimmune disorders. Individual components are also available. Also offered is the ANAlyzer without ANA panel, #1005, as a more focused evaluation for patients who have already been identified as ANA positive. Panel #1000 is more extensive since it can identify atypical autoimmune disorders as well. ANA with Reflex to ANAlyzer #1118 is also available. It includes the same components as panel #1000, where no specific antibody assays are performed on specimens with negative ANA screen
Custom Panel: No


Days Performed: Tuesday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 36378
Alternate Test Names: ANAlyzer®; ANAlyzeR™ ANA, IFA with Reflex Titer/Pattern, Syst; Lupus (12) Panel; Lupus Analyzer
Included Tests: ANA Screen,IFA, with Reflex to Titer and Pattern;DNA (ds) Antibody, Crithidia IFA with Reflex to Titer;Chromatin (Nucleosomal) Antibody;Sm Antibody;Sm/RNP Antibody; RNP Antibody; Sjogren's Antibodies (SS-A, SS-B); Scleroderma Antibody (Scl-70);Jo-1 Antibody;Centromere B Antibody; Complement Component C3c and C4c;Cardiolipin Antibodies (IgA, IgG, IgM); Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM);Rheumatoid Factor (IgA, IgG, IgM); Cyclic Citrullinated Peptide (CCP) Antibody (IgG);14.3.3 eta Protein;Thyroid Peroxidase Antibodies (TPO)
CPT Coding: 83516, 86038, 86160 x 2, 86225, 86235 x 5, 86376, 86431 (If the ANA screen (86038) is positive, an ANA Pattern/Titer will reflex at an additional charge (CPT 86039))

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