ANA Screen, IFA, with Reflex to Titer and Pattern/Lupus Panel 4

Last Modified: 1/21/2019 11:25:26 AM


Specimen Requirements:

4.0 mL Serum from a Red Top Tube in a Plastic Vial

Minimum Volume: 2.0 mL Serum
Transport & Storage: Temperature/Stability: 48 hours Ambient
7 days Refrigerated (transport)
30 days Frozen
Rejection Criteria: Gross hemolysis, grossly lipemic, grossly icteric
Reference Range:

ANA Screen, IFA:
Complement Component C3c: Female < 1 years: Call Client
Services Both < 1 years: Call Client Services Female
< 15 years: 80 - 173 Male < 15 years:
80 - 170 Female < 15 years: 82 - 173
Female < 81 years: 82 - 193 Male < 81
years: 82 - 185 Female < 81 years:
83 - 193 Female >= 81 years: Call Client Services
Both >= 81 years: Call Client Services mg/dL
Complement Component C4c: Female < 1 years: Call Client
Services Both < 1 years: Call Client Services Female
< 15 years: 13 - 46 Male < 15 years:
14 - 44 Female < 15 years: 13 - 46
Female < 81 years: 15 - 57 Male < 81
years: 15 - 53 Female < 81 years:
15 - 57 Female >= 81 years: Call Client Services
Both >= 81 years: Call Client Services mg/dL
DNA (ds) Antibody: < 5 IU/mL
Ribosomal P Antibody: < 1.0 AI
Sm Antibody: < 1.0 AI
SM/RNP Antibody: < 1.0 AI
Sjogrens Antibody (SS-A): < 1.0 AI
Sjogrens Antibody (SS-B): < 1.0 AI
Thyroid Peroxidase Antibodies: < 9 IU/mL
Scl-70 Antibody: < 1.0 AI
Rheumatoid Factor: < 14 IU/mL
ANA Pattern:
ANA Titer: <1:40 titer

Test Comments: If the ANA Screen is Positive the ANA pattern
and titer will be performed at an additional charge (add
CPT code(s): 86039).
Methodology: Immunoassay; Immunoturbidometric
Clinical Significance: This panel is used to aid in the screening and diagnosis of autoimmune disorders such as Mixed Connective Tissue Diseases, Systemic Lupus Erythematosus, Sjogren Syndrome, CREST syndrome (calcinosis, Raynaud's syndrome, esophageal dysfunction, sclerodactyly and telangiectasia), Idiopathic Raynaud's Syndrome, drug induced lupus, ANA-negative lupus, diffuse scleroderma, etc., also including autoimmune thyroiditis, rheumatoid arthritis, and atypical autoimmune disorders. Individual components are also available. Also offered is the ANAlyzer without ANA panel, #1005, as a more focused evaluation for patients who have already been identified as ANA positive. Panel #1000 is more extensive since it can identify atypical autoimmune disorders as well. ANA with Reflex to ANAlyzer #1118 is also available. It includes the same components as panel #1000, where no specific antibody assays are performed on specimens with negative ANA screen
Custom Panel: No

PRODUCTION SCHEDULE

Days Performed: Tuesday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: MSOT
EPIC Test Code:
Alternate Test Names: ANAlyzer®; Lupus (12) Panel; Lupus Analyzer
CPT Coding: 83516, 86038, 86160 x 2, 86225, 86235 x 5, 86376, 86431 (If the ANA screen (86038) is positive, an ANA Pattern/Titer will reflex at an additional charge (CPT 86039))

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