17-Hydroxyprogesterone

Overview

  • EPIC Code:
  • LAB720
  • Soft Test Code:
  • 17PRO
  • Send Out Test Code:
  • 17180
Alternate Names
  • 17 - Hydroxyprogesterone
  • 17-Alpha-Hydroxprogesterone
  • 17-Hydroxyprogesterone
  • 17-OHP
  • 17-OHProgesterone
  • OH-Progesterone
Clinical Significance

17-Hydroxyprogesterone is elevated in patients with Congenital Adrenal Hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.


Specimen Collection & Preparation

Specimen Requirements:

-OR-

0.5 mL Serum from a Red Top Tube in a Plastic Vial
Minimum Volume:
0.25 mL Serum*

* This volume does not allow for repeat testing

Specimen Information:

Separate serum after clotting. Ship serum refrigerated or frozen.


Rejection Criteria:

Gross hemolysis

Serum Separator Tube (SST)


Transport and Storage:
  • Ambient: 48 Hours
  • Refrigerated: 7 Days

    Transport

  • Frozen (-20 C or colder): 2 Years

Clinical Interpretation

Reference Range:

Adult Males

18-30 years 32-307 ng/dL
31-40 years 42-196 ng/dL
41-50 years 33-195 ng/dL
51-60 years 37-129 ng/dL


Adult Females

Pre-Menopausal Mid Follicular 23-102 ng/dL
Pre-Menopausal Surge 67-349 ng/dL
Pre-Menopausal Mid Luteal 139-431 ng/dL
Postmenopausal Phase ≤45 ng/dL

Pregnancy

First Trimester 78-457 ng/dL
Second Trimester 90-357 ng/dL
Third Trimester 144-578 ng/dL


Pediatric

Cord Blood** 1000-3000 ng/dL
Premature Infants** (31-35 weeks) ≤405 ng/dL
Term Infants (12 hrs)** <460 ng/dL
Values decline gradually to prepubertal levels 
   
Male and Female  
  <30 days Not established
  1-11 months ≤147 ng/dL
  1 year ≤139 ng/dL
  2 years ≤134 ng/dL
  3 years ≤131 ng/dL
  4 years ≤131 ng/dL
  5 years ≤133 ng/dL
  6 years ≤137 ng/dL
  7 years ≤145 ng/dL
  8 years ≤154 ng/dL
  9 years ≤166 ng/dL
  10 years ≤180 ng/dL
  11 years ≤196 ng/dL
  12 years ≤213 ng/dL
  13 years ≤233 ng/dL
  14 years ≤254 ng/dL
  15 years 19-276 ng/dL
  16 years 23-300 ng/dL
  17 years 26-325 ng/dL


Tanner Stages**

II-III Males 12-130 ng/dL
II-III Females 18-220 ng/dL
IV-V Males 51-190 ng/dL
IV-V Females 36-200 ng/dL

 


Methodology:
  • Chromatography / Mass Spectrometry
Clinical Significance

17-Hydroxyprogesterone is elevated in patients with Congenital Adrenal Hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

2 to 5 days


Coding & Compliance

CDM

01422803


CPT Coding

83498