Hemoglobin Electrophoresis Cascade

Last Modified: 2/15/2021 1:30:27 PM


  Medicare Medical Necessity Restrictions May Apply
Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 10.0 mL Whole Blood in (2) two Lavender Top Tubes - EDTA
Collection Instructions: Patient age required on order with all other requirements

Recent Transfusion information should be sent with specimen

Send in Lavendar tubes / Do not aliquot

Minimum volume notes
3mL if multiplex ligation-dependent probe amplification is desired
Minimum Volume: 1.0 - 3.0 mL Whole Blood
Transport & Storage: Temperature/Stability: 7 days Refrigerated
Reference Range:

Hemoglobin A:
1-30 days: 5.9-77.2%
1-2 months: 7.9-92.4%
3-5 months: 54.7-97.1%
6-8 months: 80.0-98.0%
9-12 months: 86.2-98.0%
13-17 months: 88.8-98.0%
18-23 months: 90.4-98.0%
> or =24 months: 95.8-98.0%

 Hemoglobin A2:
1-30 days: 0.0-2.1%
1-2 months: 0.0-2.6%
3-5 months: 1.3-3.1%
> or =6 months: 2.0-3.3%
 
Hemoglobin F
1-30 days: 22.8-92.0%
1-2 months: 7.6-89.8%
3-5 months: 1.6-42.2%
6-8 months: 0.0-16.7%
9-12 months: 0.0-10.5%
13-17 months: 0.0-7.9%
18-23 months: 0.0-6.3%
> or =24 months: 0.0-0.9%

Varient: No abnormal variants
Varient 2:No abnormal variants
Varient 3:No abnormal variants

Critical Ranges:  
Test Comments:  
Methodology: Multiple
Clinical Significance:

Diagnosis of thalassemias and hemoglobin variants
Evaluation of unexplained microcytosis

Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 2 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Mayo Laboratory
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: HBEL1
Alternate Test Names: Alpha Globin Variant; A2 Hemoglobin; Barts Hemoglobin; Beta Globin Variant; Beta-Thalassemia; Fetal Hemoglobin; fetaldex (Hemoglobin F); Hemoglobin A2; Hemoglobin Cascade; Hemoglobin Electrophoresis Cascade Level 1; Hemoglobin F; Hemoglobin Mass Spec Studies; Hemoglobin Molecular studies; Hemoglobin S, quant; Hemoglobin Variant; Hemoglobin-H Disease; HGB (Hemoglobin) Electrophoresis; Isoelectric Focusing; Sickling Test
Included Tests:  
CPT Coding: 83020, 83021, 82664, 83068, 83789, 88184

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