AccuType (TM) CP, Clopidogrel CYP2C19 Genotype

Last Modified: 2/4/2019 1:44:02 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 4.0 mL Whole Blood in a Lavender Top Tube - EDTA
Collection Instructions:  
Minimum Volume: 2.0 mL Whole Blood
Transport & Storage: Temperature/Stability: 8 days Ambient (transport)
30 days Refrigerated 
49 days Frozen

Speicmen Stability is crucial, ship immediately.
Reference Range:

Refer to Interpretive Results

Critical Ranges:  
Test Comments:  
Methodology: PCR Single Nucleotide Primer Extension Reaction
Clinical Significance: The cytochrome P450 gene products are responsible for metabolizing a large number of widely prescribed drugs. Clopidogrel [Plavix (R)] is metabolized by cytochrome P450 2C19 (CYP2C19, S-mephenytoin 4-prime-hydroxylase) to its active form. Poor metabolizers (PM) will require increased dosage to obtain therapeutic levels, while ultra-extensive metoblizers (UM) will require a decreased dosage, due to higher than normal rates of drug metabolism. CYP2C19 catalyzes the hydroxylation of a number of
clinically important drugs, including omeprazole, proguanil, hexobarbital, imipramine, and to a lesser extent, propranolol and diazepam. CYP2C19 loss-of- function alleles were shown to be associated with a higher rate of subsequent cardiovascular events among patients with an acute myocardial infarction and who were receiving clopidogrel treatment (N Engl J Med. 2009;
360:363-375).
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 7 to 11 days
Days Performed: Tuesday, Friday
Sites Performed: Quest - Valencia to San Juan Capistrano
PHL Test Code: PLVR
EPIC Test Code: IMO98
Send Out Test Code: 16924
Alternate Test Names: ACCUTYPEâ„¢, CLOPIDOGREL; Clopidogrel CYP2C19; Clopidogrel CYP2C19 Genotype; Cytochrome P450; Cytochrome P450 2C19; Plavix Resistance
Included Tests:  
CPT Coding: 81225

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