Last Modified:
2/2/2022 12:55:19 PM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
4.0 mL Whole Blood in a Lavender Top Tube - EDTA
Collection Instructions:
Minimum Volume:
2.0 mL Whole Blood
Transport & Storage: Temperature/Stability:
8 days Ambient (transport)
30 days Refrigerated
49 days Frozen
Speicmen Stability is crucial, ship immediately.
Reference Range:
Refer to Interpretive Results
Critical Ranges:
Test Comments:
Methodology:
PCR Single Nucleotide Primer Extension Reaction
Clinical Significance:
The cytochrome P450 gene products are responsible for metabolizing a large number of widely prescribed drugs. Clopidogrel [Plavix (R)] is metabolized by cytochrome P450 2C19 (CYP2C19, S-mephenytoin 4-prime-hydroxylase) to its active form. Poor metabolizers (PM) will require increased dosage to obtain therapeutic levels, while ultra-extensive metoblizers (UM) will require a decreased dosage, due to higher than normal rates of drug metabolism. CYP2C19 catalyzes the hydroxylation of a number of
clinically important drugs, including omeprazole, proguanil, hexobarbital, imipramine, and to a lesser extent, propranolol and diazepam. CYP2C19 loss-of- function alleles were shown to be associated with a higher rate of subsequent cardiovascular events among patients with an acute myocardial infarction and who were receiving clopidogrel treatment (N Engl J Med. 2009;
360:363-375).
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
7 to 11 days
Days Performed:
Tuesday, Friday
Sites Performed:
Quest - Chantilly to San Juan Capistrano
PHL Test Code:
PLVR
EPIC Test Code:
IMO98
Send Out Test Code:
16924
Alternate Test Names:
ACCUTYPE™, CLOPIDOGREL; Clopidogrel CYP2C19; Clopidogrel CYP2C19 Genotype; Cytochrome P450; Cytochrome P450 2C19; Plavix Resistance
Included Tests:
CPT Coding:
81225
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