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IGF Binding Protein-3
Last Modified:
8/15/2019 1:43:21 PM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
1.0 mL Serum from a
Red Top Tube
in a Plastic Vial
Collection Instructions:
Minimum Volume:
0.5 mL Serum
Transport & Storage: Temperature/Stability:
7 days Ambient
14 days Refrigerated
1 year Frozen
Rejection Criteria:
Gross hemolysis and gross lipemia
Reference Range:
Refer to Interpretive Results
Critical Ranges:
Test Comments:
Methodology:
Immunoassay (IA)
Clinical Significance:
Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II.
IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
1 to 2 days
Days Performed:
Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed:
Quest - Chantilly
PHL Test Code:
IGF3
EPIC Test Code:
IMO127
Send Out Test Code:
34458
Alternate Test Names:
IGBP3; IGFBP 3; IGFBP-3; Insulin Growth Factor 3; Insulin-Like Growth Factor Binding Protein
Included Tests:
CPT Coding:
82397
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