IGF Binding Protein-3

Last Modified: 8/15/2019 1:43:21 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:  
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 7 days Ambient
14 days Refrigerated
1 year Frozen
Rejection Criteria: Gross hemolysis and gross lipemia
Reference Range:
Refer to Interpretive Results
Critical Ranges:  
Test Comments:  
Methodology: Immunoassay (IA)
Clinical Significance: Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II.
IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction
Custom Panel: No


Turn Around Time: 1 to 2 days
Days Performed: Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: IGF3
EPIC Test Code: IMO127
Send Out Test Code: 34458
Alternate Test Names: IGBP3; IGFBP 3; IGFBP-3; Insulin Growth Factor 3; Insulin-Like Growth Factor Binding Protein
Included Tests:  
CPT Coding: 82397

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