IGF Binding Protein-3

Overview

  • EPIC Code:
  • IMO127
  • Soft Test Code:
  • IGF3
  • Send Out Test Code:
  • 34458
Alternate Names
  • IGBP3
  • IGFBP 3
  • IGFBP-3
  • Insulin Growth Factor 3
  • Insulin-Like Growth Factor Binding Protein
Clinical Significance

Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II.
IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a Red Top Tube in a Plastic Vial


Transport And Storage

7 days Ambient
14 days Refrigerated
1 year Frozen


Collection Instructions

 


Minimum Volume

0.5 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Refer to Interpretive Results


Methodology:
  • Immunoassay (IA)
Clinical Significance

Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II.
IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in acromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

1 to 2 days


Coding & Compliance

CDM

00913526


CPT Coding

82397