Chromosome Analysis, Hematologic Maligancy

Last Modified: 1/7/2020 2:19:23 PM

Medical Necessity Documentation:  
Client Notes: Order must include the reason for testing and a current CBC report and a stained peripheral blood slide
Patient Preparation: Anti-leukemic drug therapy may suppress cell division. The patient should not have received these drugs within 6 weeks of sample collection.
Specimen Requirements: 3.0 mL Bone Marrow in a Green Top Tube - Na Heparin 
Collection Instructions: Bone Marrow must contain 10% less mature myelocytes, pros or blasts

Clinical history/reason for referral is required with test order. Previous bone marrow transplant or therapy information, if applicable, should be provided with test order.

Minimum Volume: 1.0 mL Bone Marrow;
Neonatal Volume: Infants: 2-3 mL (pediatric 3mL vacutainer)
Transport & Storage: Temperature/Stability: Ambient (Transport)

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination.
Rejection Criteria: Frozen
Reference Range: Reference Range Not Established
Critical Ranges:  
Test Comments:  This test may be replaced by one of the following Bill Codes, if the complete test cannot be performed from the submitted specimen: 4473 - Tissue Culture for Hematologic Disorder; 416 - Cytogenetics Communication, if a communication is required.
Methodology: Culture • Karyotype • Microscopy
Clinical Significance: Cytogenetics of hematologic disorders attempts to define and interpret chromosomal aberrations that occur in neoplastic cells associated with leukemia, lymphoma and other hematologic malignancies. Chromosome abnormalities in cancer cells of patients with malignant hematologic disorders including acute and chronic myeloid and lymphoid leukemias, myelodysplastic and myeloproliferative disorders, lymphomas and unexplained anemias may correlate with the diagnosis, prognosis, treatment and etiology of disease.
Custom Panel: No


Turn Around Time: 8 to 9 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: CHRON
EPIC Test Code: LAB3135
Send Out Test Code: 14600
Alternate Test Names: Acute Lymphoblastic Leukemia (ALL); Chronic Myelogenous Leukemia (CML); Myelodysplastic Syndrome (MDS); Myeloproliferative Disorders (MPD); Philadelphia Chromosome
Included Tests:  
CPT Coding: 88237, 88264

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