HTLV I/II Antibody, w/Reflex to Confirmatory Assay

Last Modified: 11/12/2019 2:26:30 PM


  Medicare Medical Necessity Restrictions May Apply
Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 1.0 mL Serum in a SST Gold Top Tube
Collection Instructions:  
Minimum Volume: 0.7 mL Serum
Transport & Storage: Temperature/Stability: 7 days Refrigerated (transport)
30 days Frozen
Rejection Criteria: Received Ambient
Reference Range:

HTLV-I/-II Antibody
Nonreactive

HTLV I/II, Westernblot
WB: Negative for GD21, p19, p24, p26, p28, p32, p36, gp46, p53, rgp46-I, rgp46-II bands
Negative - No viral bands present
Indeterminate - Viral bands present, but criteria for a positive result are not met.
Positive Criteria - Viral bands present
The criteria band reactivities required for positive HTLV antibody results are summarizied as follows:
For HTLV-I: p19, GD21, and rgp46-I;
For HTLV-II: p24, GD21, and rgp46-II;
For HTLV positive but untypable: p19 or p24, plus GD21.

HTLV Western Blot should be interpreted in conjunction with the HTLV screening immunoassay
Critical Ranges:  
Test Comments: If the HTLV-I/II Antibody is Reactive, then HTLV-I/II, Western Blot, will be performed at an additional charge.
Methodology: Western Blot; Immunoassay; Chemiluminescence Assay
Clinical Significance: HTLV-I is associated with adult T-cell lymphoblastic leukemia and B-cell chronic lymphocytic leukemia. HTLV-II is less common and is associated with neoplasias of the CD8 T-lymphocytes. Blood donor screening for HTLV began in 1998. Western Blot is used for confirmation of Antibody testing.
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 2 to 3 days
Days Performed: Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: HTLVP
EPIC Test Code: IMO96
Send Out Test Code: 36175
Alternate Test Names: HTLV I/II Antibody, w/Reflex to Western Blot; HTLV I/II reflex to WB; HTLV I/II W/REFLEX WB
Included Tests: HTLV-I/-II Antibody; HTLV I/II, Western Blot
CPT Coding: 86790 (reflexes 86689)

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