Clostridium difficile GDH/Toxin

Last Modified: 8/23/2019 6:06:20 AM

Medical Necessity Documentation:

Testing may only be performed every 14 days

Patient Preparation: Patients must be symptomatic. 
 No "test of cure" specimens should be submitted.  Patients may remain positive for long periods without symptoms.
Specimen Requirements: 5.0 mL unformed Feces in a Non-Sterile Yellow Capped Container
Collection Instructions:

Only specimens that conform to the container shape will be tested.

Transport & Storage: Temperature/Stability: ≤72 hours refrigerated
>72 hours frozen.
Rejection Criteria: Formed stools;Specimens received within 30 days of a pos result; or received within 14 days of a previous neg result; In a gel fecal transport media (C-Blair red capped swab);received in 10% or merthiolate or sodium acetate formalin;polyvinyl alcohol
Reference Range: Negative for GDH by EIA
Negative for Toxins by EIA
Test Comments: Positive GDH and Negative Toxin will reflex PCR testing for toxin gene.
Methodology: EIA
Clinical Significance: Clostridium difficile infection is a serious disease causing diarrhea, colitis, and even pseudomembranous colitis that develops as a result of antibiotic treatment.  It may also occur due to nosocomial transmission.  Recently, community acquired infections have been found with patients who have not received antibiotics.  It is important that true cases be identified quickly to allow treatment which will prevent serious sequelae for the patient and possible nosocomial transmission.
Custom Panel: No


Turn Around Time: 8 to 12 hours
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Parkview Regional Medical Center
PHL Test Code: CDGTO
Alternate Test Names: C diff; C. diff Toxin; cdiff; Clostridum difficile; GDH; Toxins
CPT Coding: 87324; 87449

Go back to the top of the page.