Cryoglobulin Screen with Reflex to Cryoglobulin Panel

Last Modified: 2/23/2021 1:06:44 PM

Medical Necessity Documentation:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
Patient Preparation: Overnight fasting is required
Specimen Requirements: 10.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions: Allow serum sample to clot for one (1) hour in a 37° C water bath, oven, incubator, or heat block. 
After clotting, centrifuge the specimen for 10 minutes at 1600 RCF(G). utilizing one of the 3 options below:

1) In a "warm" centrifuge at 37° C.
2) In a bench-top centrifuge placed in a "warm room" at 37° C.
3) At room temperature, in a bench-top centrifuge prewarmed by running it for 10 minutes at 1600 RCF(G).
After centrifuging, decant serum into a screw-cap vial.
Transport at room temperature.
Note: no other tests can be added to the tube; cryocrit and cryoglobulin evaluation only.
Minimum Volume: 3.5 mL Serum
Transport & Storage: Temperature/Stability: 72 hours Ambient only
Rejection Criteria: Gross hemolysis • Lipemia • Icteric • Serum separator tube (SST)
Reference Range:
Cryoglobulin, QL Negative in normal individuals
Methodology: Cryocrit • Electrophoresis • Immunodiffusion (ID) • Immunofixation (if needed) • Rate Nephelometry
Clinical Significance: Cryoglobulin Screen with Reflex to Cryoglobulin Panel - Cryoglobulins are proteins that precipitate from serum at temperatures below 37° C. Most precipitate when serum is cooled at 4° C, but some gel even at room temperature. The gel or precipitate must redissolve at 37° C to be classified as a cryoglobulin
Custom Panel: No


Turn Around Time: 6 to 8 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: 37358
CPT Coding: 82595

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