Immunoglobulin G Subclasses Panel

Last Modified: 6/27/2019 7:14:46 AM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

2.0 mL Serum from a Red Top Tube in a Plastic Vial

Collection Instructions:  
Minimum Volume: 1.0 mL
Transport & Storage: Temperature/Stability: 72 hours Ambient
10 days Refrigerated
30 days Frozen
Reference Range:

IgG Subclass 1: 
0 – 1 year: 194 – 842 mg/dL
2 – 3 years: 315 – 945 mg/dL
4 – 5 years: 306 – 945 mg/dL
6 – 7 years: 288 – 918 mg/dL
8 – 9 years: 432 – 1020 mg/dL
10 – 11 years: 423 – 1060 mg/dL
12 – 13 years: 342 – 1150 mg/dL
14 – 17 years: 315 – 855 mg/dL
> 17 years: 382 – 929 mg/dL

IgG Subclass 2: 
0 – 1 year: 23 – 300 mg/dL
2 – 3 years: 36 – 225 mg/dL
4 – 5 years: 61 – 345 mg/dL
6 – 7 years: 44 – 375 mg/dL
8 – 9 years: 72 – 430 mg/dL
10 – 11 years: 76 – 355 mg/dL
12 – 13 years: 100 – 455 mg/dL
14 – 17 years: 64 – 495 mg/dL
> 17 years: 242 – 700 mg/dL

IgG Subclass 3:
0 – 1 year: 19 – 85 mg/dL
2 – 3 years: 17 – 68 mg/dL
4 – 5 years: 10 – 122 mg/dL
6 – 7 years: 16 – 85 mg/dL
8 – 9 years: 13 – 85 mg/dL
10 – 11 years: 17 – 173 mg/dL
12 – 13 years: 28 – 125 mg/dL
14 – 17 years: 23 – 196 mg/dL
> 17 years: 22 – 176 mg/dL

IgG Subclass 4:
0 – 1 year: 1 – 78 mg/dL
2 – 3 years: 1 – 54 mg/dL
4 – 5 years: 2 – 112 mg/dL
6 – 7 years: 1 – 99 mg/dL
8 – 9 years: 2 – 93 mg/dL
10 – 11 years: 2 – 115 mg/dL
12 – 13 years: 4 – 136 mg/dL
14 – 17 years: 11 – 157 mg/dL
> 17 years: 4 – 86 mg/dL

IgG Total: 
1 - 28 days: 250-600 mg/dL
1 - 3 Months: 200-600 mg/dL
4 - 6 Months: 160-590 mg/dL
7 - 11 Months: 160-800 mg/dL
1 year: 280-1040 mg/dL
2 years: 330-1120 mg/dL
3 - 5  years: 390-1360 mg/dL
6 - 8  years: 440 - 1470 mg/dL
9 - 11 years: 480-1530 mg/dL
12 - 16 years: 500-1590 mg/dL
17 - 60 years: 600-1640 mg/dL
61 years or older:  600 - 1540 mg/dL
Critical Ranges:  
Test Comments:  
Methodology: Nephelometry
Clinical Significance: Assess humoral immunity. Immunoglobulin G (IgG) is the most abundant immunoglobulin of extravascular liquids (65%) and of serum (70-75%). Antibodies of the IgG class are produced in response to most bacteria and viruses. IgG consists of two heavy and two light chains and contains less than 3% carbohydrate. IgG has four subclsses: IgG1, IgG2, IgG3, and IgG4. Both IgG1 and IgG3 bind firmly to the Fc receptors of phagocytic cells, activate killer monocytes (K cells), and cross the placenta
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Valencia
PHL Test Code: IGGSB
EPIC Test Code: IMO212
Send Out Test Code: 1623
Alternate Test Names: IgG Subclass 1, 2, 3, & 4; IgG Subclasses Panel
Included Tests: IgG Subclass 1; IgG Subclass 2; IgG Subclass 3; IgG Subclass 4; IgG Total
CPT Coding: 82784, 82787 x 4

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