Adrenocorticotropic Hormone, Plasma

Last Modified: 2/4/2019 2:04:16 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 1.5 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial
Collection Instructions: Draw specimens between 7 a.m. and 10 a.m. If drawn during any other time, the reference ranges do not apply. 
Centrifuge immediately after collection to separate plasma from cells. 
Transfer plasma to a plastic specimen transport container and mark the specimen type as plasma on the container. 
Freeze immediately.
Minimum Volume: 0.5 mL
Transport & Storage: Temperature/Stability:

28 days Frozen

Rejection Criteria: Gross Hemolysis; Received thawed, Ambeint: or Refrigerated
Reference Range: < 3 years: Reference Range Not Established
3 years to 17 years: 9 - 57 pg/mL
 > or = 18 years: 6 - 50 pg/mL
Critical Ranges:  
Test Comments: Limitations: With patients receiving more than 5mg/day of biotin, a sample should be taken no sooner than eight hours after previous dose. Patients treated with monoclonal mouse antibodies may have inaccurate results. High titer of antibodies such as streptavidin and ruthenium may cause interference. Due to its correlation with cortisol levels, ACTH concentration is affected by stress. Any single measure may be within the reference range for patients with increased production (Cushing's disease) or minimal production of ACTH.
Methodology: Immunoassay
Clinical Significance: Determination of ACTH is useful in differentiating between primary and secondary adrenocortical hypo- and hyperfunctional disorders: Addison's disease, Cushing's syndrome, adrenal carcinoma, ectopic ACTH syndrome, and adrenal nodular hyperplasia.
Custom Panel: No


Turn Around Time: 2 to 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: ACT
EPIC Test Code: LAB511
Send Out Test Code: 211
Alternate Test Names: ACTH
Included Tests:  
CPT Coding: 82024

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