Metanephrines, 24-hour Urine

Last Modified: 5/17/2019 3:45:16 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation: It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection
Specimen Requirements: 5.0 mL Urine aliquot from a well mixed 24 hour Urine Collection in a Plastic Container
Collection Instructions: Order must include the patients age on Order and Urine Vial

1. When starting the 24-hour period, urinate and discard (throw-away) this specimen. NOTE THE TIME
2. From that time on, collect all urine by urinating into a clean container and transfer into the provided container. 
3. Try to pass the last urine just prior to the end of the 24 hour period. Add this urine into the container. 
4. Urine Specimen should be kept refrigerated during and after collection. 

For patient collection instruction sheet see Addendum D
For Spanish patient collection instruction sheet see Addendum D
For Burmese patient collection instruction sheet see Addendum D
For Arabic patient collection instruction sheet see Addendum D

Minimum Volume: 1.5 mL Urine
Transport & Storage: Temperature/Stability: 7 days Ambient
8 days Refrigerated (preserved)
30 days Frozen (unpreserved)
Reference Range:
Metanephrines, 24-Hour Urine    
Age Reference Range UOM
3 months-4 years 25-117 mcg/24 h
5-9 years 11-139 mcg/24 h
10-13 years 51-275 mcg/24 h
14-17 years 40-189 mcg/24 h
18-29 years 25-222 mcg/24 h
30-39 years 36-190 mcg/24 h
40-49 years 58-203 mcg/24 h
≥50 years 90-315 mcg/24 h
Normetanephrines, 24-Hour Urine    
3 months-4 years 54-249 mcg/24 h
5-9 years 31-398 mcg/24 h
10-13 years 67-503 mcg/24 h
14-17 years 69-531 mcg/24 h
18-29 years 40-412 mcg/24 h
30-39 years 35-482 mcg/24 h
40-49 years 88-649 mcg/24 h
≥50 years 122-676 mcg/24 h
Metanephrines, Total 24-Hour Urine    
3 months-4 years 79-345 mcg/24 h
5-9 years 49-408 mcg/24 h
10-13 years 110-714 mcg/24 h
14-17 years 107-741 mcg/24 h
18-29 years 94-604 mcg/24 h
30-39 years 115-695 mcg/24 h
40-49 years 182-739 mcg/24 h
≥50 years 224-832 mcg/24 h
Critical Ranges:  
Test Comments:  
Methodology: Liquid Chromatography/Tandem Mass Spectrometry
Clinical Significance: Test is useful in the evaluation of pheochromocytoma.
Custom Panel: No


Turn Around Time: 3 to 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: MET1
EPIC Test Code: LAB409
Send Out Test Code: 14962 / 14962X
Alternate Test Names: Metanephrines, Fractionated 24-Hour Urine
Included Tests: Metanepharines; Normetanephrines; Total Metanepharines
CPT Coding: 83835

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