Metanephrines, 24-hour Urine

Overview

  • EPIC Code:
  • LAB409
  • Soft Test Code:
  • MET2
  • Send Out Test Code:
  • 14962
Alternate Names
  • Metanephrines Total & Fractionated Ur
  • Metanephrines, Fractionated 24-Hour Urine
Included Tests

Metanepharines; Normetanephrines; Total Metanepharines


Clinical Significance

Test is useful in the evaluation of pheochromocytoma.


Specimen Collection & Preparation

Patient Preparation

It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection


Specimen Requirements

5.0 mL Urine aliquot from a well mixed 24 hour Urine Collection in a Plastic Container


Transport And Storage

Preserved Urine
10 days Ambient
14 days Refrigerated 
90 days Frozen 

Unpreserved Urine
Unacceptable Ambient
Unacceptable Refrigerated
30 days Frozen


Collection Instructions

Order must include the patients age on Order and Urine Vial

1. When starting the 24-hour period, urinate and discard (throw-away) this specimen. NOTE THE TIME
2. From that time on, collect all urine by urinating into a clean container and transfer into the provided container. 
DO NOT URINATE DIRECTLY INTO CONTAINER.
3. Try to pass the last urine just prior to the end of the 24 hour period. Add this urine into the container. 
4. Urine Specimen should be kept refrigerated during and after collection. 

Printable Patient Collection Instructions

English 24 Hour Urine Collection

Spanish 24 Hour Urine Collection 

Burmese 24 Hour Urine Collection

Arabic 24 Hour Urine Collection 


Minimum Volume

1.5 mL Urine


Neonatal Volume

Clinical Interpretation

Reference Range:

Metanephrines, 24-Hour Urine    
Age Reference Range UOM
3 months-4 years 25-117 mcg/24 h
5-9 years 11-139 mcg/24 h
10-13 years 51-275 mcg/24 h
14-17 years 40-189 mcg/24 h
18-29 years 25-222 mcg/24 h
30-39 years 36-190 mcg/24 h
40-49 years 58-203 mcg/24 h
≥50 years 90-315 mcg/24 h
     
Normetanephrines, 24-Hour Urine    
3 months-4 years 54-249 mcg/24 h
5-9 years 31-398 mcg/24 h
10-13 years 67-503 mcg/24 h
14-17 years 69-531 mcg/24 h
18-29 years 40-412 mcg/24 h
30-39 years 35-482 mcg/24 h
40-49 years 88-649 mcg/24 h
≥50 years 122-676 mcg/24 h
     
Metanephrines, Total 24-Hour Urine    
3 months-4 years 79-345 mcg/24 h
5-9 years 49-408 mcg/24 h
10-13 years 110-714 mcg/24 h
14-17 years 107-741 mcg/24 h
18-29 years 94-604 mcg/24 h
30-39 years 115-695 mcg/24 h
40-49 years 182-739 mcg/24 h
≥50 years 224-832 mcg/24 h


Methodology:
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)
Clinical Significance

Test is useful in the evaluation of pheochromocytoma.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 5 days


Coding & Compliance

CDM

01426899


CPT Coding

83835