Hu Antibody Screen with Reflex to Titer and Western Blot

Overview

  • EPIC Code:
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 37053
Alternate Names
  • ANNA-1
  • HU Ab
  • HU Antibody
  • Neuronal Ab
Clinical Significance

Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.


Specimen Collection & Preparation

Patient Preparation

Fasting


Specimen Requirements

1.0 mL Serum from a Red Top Tube in a Plastic Vial


Transport And Storage

7 days Ambient
14 days Refrigerated
21 days Frozen


Collection Instructions


Minimum Volume

0.3 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Hu Ab Screen, IFA Negative
  Hu Ab, WB Negative
  Hu Ab Titer <1:40


Test Comments:

If Hu Antibody Screen, IFA is positive, Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is positive, Hu Antibody Titer will be performed at an additional charge (CPT code(s): 86256).


Methodology:
  • Immunofluorescence Assay (IFA), Western Blot (WB)
Clinical Significance

Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.


Production Schedule

Sites Performed
  • Quest - Chantilly to San Juan Capistrano
Days Performed
Monday
Wednesday
Friday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

4 to 6 days


Coding & Compliance

CDM

00913333


CPT Coding

86255