Hu Antibody Screen with Reflex to Titer and Western Blot

Last Modified: 7/14/2016 12:15:49 PM

Patient Preparation: Fasting
Specimen Requirements: 1.0 mL Serum from a Red Top Tube in a Plastic Vial
Minimum Volume: 0.3 mL Serum
Transport & Storage: Temperature/Stability: 7 days Ambient
14 days Refrigerated
21 days Frozen
Reference Range:
Hu Ab Screen, IFA Negative
  Hu Ab, WB Negative
  Hu Ab Titer <1:40
Test Comments: If Hu Antibody Screen, IFA is positive, Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is positive, Hu Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
Methodology: Immunofluorescence Assay (IFA) • Western Blot (WB)
Clinical Significance:

Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.

Custom Panel: No


Turn Around Time: 4 to 6 days
Days Performed: Monday, Wednesday, Friday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 37053
Alternate Test Names: ANNA-1; HU Ab; HU Antibody; Neuronal Ab
CPT Coding: 86255

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