First Trimester Screen, Hyperglycosylated hCG

Overview

  • EPIC Code:
  • LAB2883
  • Soft Test Code:
  • FTSOH
  • Send Out Test Code:
  • 16020
Alternate Names
  • 1st Trimester,Down Syndrome and Trisomy 18 Screen
  • h-hCG
  • Hyperglycosylated hCG (h-hCG)
  • Invasive Trophoblast Antigen (ITA)
  • MSS
  • Nuchal Translucency (NT)
  • Pregnancy-associated Plasma Protein-A (PAPP-A)
Included Tests

h-hCG (hyperglycosylated hCG); PAPP-A (Pregnancy-associated Plasma Protein); risk calculation which includes NT (Nuchal Translucency)


Clinical Significance

To screen for Down syndrome and trisomy 18 at 9.0-13.9 weeks gestation


Specimen Collection & Preparation

Specimen Requirements

1.5 mL Serum from a Red Top Tube in a Plastic Vial


Transport And Storage

7 days Ambient
7 days Refrigerated
60 days Frozen


Collection Instructions

The Informational Form MUST be filled out completely and submitted with specimen


Minimum Volume

0.8 mL


Neonatal Volume

Clinical Interpretation

Reference Range:

MSS Down Syndrome Risk <1:270
MSS Risk for Trisomy 18 Risk <1:100


Test Comments:

This test was developed and its performance characteristics have been determined by Quest Diagnostics. Performance characteristics refer to the analytical performance of the test.


Methodology:
  • Chemiluminescence (CL)
  • Immunoassay (IA)
Clinical Significance

To screen for Down syndrome and trisomy 18 at 9.0-13.9 weeks gestation


Documentation

Limitations: First Trimester Screen results consistent with increased risk of trisomy should be confirmed with CVS or amniotic fluid specimen. Maternal serum screening yields a low percentage of false negatives. A wide range of other chromosomal abnormalities are not identified by maternal serum screening

Research Test Only


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 5 days


Coding & Compliance

CDM

00913333


CPT Coding

84163, 82397