First Trimester Screen, Hyperglycosylated hCG

Last Modified: 3/25/2019 2:48:05 PM

Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 1.5 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions: The Informational Form MUST be filled out completely and submitted with specimen
Minimum Volume: 0.8 mL
Transport & Storage: Temperature/Stability: 7 days Ambient
7 days Refrigerated
60 days Frozen
Reference Range:
MSS Down Syndrome Risk <1:270
MSS Risk for Trisomy 18 Risk <1:100
Critical Ranges:  
Test Comments: This test was developed and its performance characteristics have been determined by Quest Diagnostics. Performance characteristics refer to the analytical performance of the test.
Methodology: Chemiluminescence (CL) • Immunoassay (IA)
Clinical Significance: To screen for Down syndrome and trisomy 18 at 9.0-13.9 weeks gestation
Documentation: Limitations: First Trimester Screen results consistent with increased risk of trisomy should be confirmed with CVS or amniotic fluid specimen. Maternal serum screening yields a low percentage of false negatives. A wide range of other chromosomal abnormalities are not identified by maternal serum screening

Research Test Only
Custom Panel: No


Turn Around Time: 3 to 5 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: FTSOH
EPIC Test Code: LAB2883
Send Out Test Code: 16020
Alternate Test Names: 1st Trimester,Down Syndrome and Trisomy 18 Screen; h-hCG; Hyperglycosylated hCG (h-hCG); Invasive Trophoblast Antigen (ITA); MSS; Nuchal Translucency (NT); Pregnancy-associated Plasma Protein-A (PAPP-A)
Included Tests: h-hCG (hyperglycosylated hCG); PAPP-A (Pregnancy-associated Plasma Protein); risk calculation which includes NT (Nuchal Translucency)
CPT Coding: 84163, 82397

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