Histoplasma Antibody, Complement Fixation

Overview

  • EPIC Code:
  • IMO413
  • Soft Test Code:
  • HISTO
  • Send Out Test Code:
  • 938
Alternate Names
  • Histoplasma Antibody, CF
  • Histoplasma Antibody, Complement Fixation, Serum
  • Histoplasma Mycelial Yeast
Included Tests

Mycelial Phase Antibody; Yeast Phase Antibody; 


Clinical Significance

This test is used for the diagnosis and prognosis of histoplasma infections. Titers ≥1:32 are highly suggestive of H. capsulatum infection. The CF test is more frequently positive with sera from chronic active pulmonary histoplasmosis than sera from primary active pulmonary disease.


Specimen Collection & Preparation

Specimen Requirements:

-OR-

1.0 mL Serum in a SST Gold Top Tube
Minimum Volume:
0.5 mL Serum *

* This volume does not allow for repeat testing

Rejection Criteria:

Gross hemolysis

Grossly lipemic

Grossly icteric


Transport and Storage:
  • Ambient (18-24°C): 7 Days

    Transport 

  • Refrigerated (2-8°C): 14 Days
  • Frozen (-20° C or colder): 30 Days

    Do not use frost free units that undergo repeated freeze/thaw cycles.

Clinical Interpretation

Reference Range:

Yeast Phase Ab <1:8 titer
Mycelial Phase Ab <1:8 titer


Interpretive Criteria

<1:8 Antibody Not Detected
≥1:8 Antibody Detected


Methodology:
  • Complement Fixation (CF)
Clinical Significance

This test is used for the diagnosis and prognosis of histoplasma infections. Titers ≥1:32 are highly suggestive of H. capsulatum infection. The CF test is more frequently positive with sera from chronic active pulmonary histoplasmosis than sera from primary active pulmonary disease.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

2 to 5 days


Coding & Compliance

CPT Coding

86317 (x2)