Amniotic Chromosome, Qualitative

Last Modified: 10/25/2021 12:23:45 PM

Medical Necessity Documentation:  
Client Notes: AneuVysion may be run simultaneously with this test utilizing the same specimen.
Patient Preparation:  
Specimen Requirements: 20 mL fresh amniotic fluid submitted in sterile, nontoxic centrifuge tubes
Collection Instructions: Indicate the patient’s gestational age; reason for study and family history.

Designate if Alpha-Fetoprotein or Acetylcholinesterase tests are needed

30 mL is preferred if other testing, e.g., microarray, FISH, is ordered
Minimum Volume: 5.0 mL amniotic fluid
Transport & Storage: Temperature/Stability:

1 day Ambient (transport/ship)
1 day Refrigerated
Unacceptable Frozen

Rejection Criteria: Frozen
Reference Range:

See Interpretive Report

Critical Ranges:  
Test Comments: Amniotic fluid cells from two or more primary cultures are studied. G-banded metaphases are analyzed microscopically for numerical and structural abnormalities, and representative metaphases (minimum of 2) are karyotyped.
Methodology: Culture; Karyotype; Microscopy
Clinical Significance: Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism and follow-up for abnormal maternal serum alpha fetoprotein or maternal screening results.
Documentation: This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis (CPT(s): 88235, 88299).
Custom Panel: No


Turn Around Time: 6 to 8 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: MSOT
EPIC Test Code: LAB2157
Send Out Test Code: 14590
Alternate Test Names: Amniotic Chromosome; Chromosome Analysis, Amniotic Fluid ; Chromosome, Amniotic Fluid; Karyotype; Karyotype, Amniotic Fluid
Included Tests:  
CPT Coding: 88235, 88269, 88280

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